FEM1B blocking peptide

FEM1B Blocking Peptide (C-Term)

• Gene Names: FEM1B; F1AA; F1A-ALPHA; FEM1-beta
• Synonyms: FEM1B; FEM1B Blocking Peptide (C-Term); Protein fem-1 homolog B; FEM1b; FEM1-beta; Fem-1-like death receptor-binding protein alpha; Fem-1-like in apoptotic pathway protein alpha; F1A-alpha; F1AA; KIAA0396; FEM1B blocking peptide

• Specificity: The synthetic peptide sequence is selected from aa 567-579 of HUMAN FEM1B
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 627

• Cellular Location: Cytoplasm. Nucleus. Note: In the nucleus, the protein level increased slightly after camptothecin (CPT) treatment. Associated with chromatin
• Tissue Location: Widely expressed. Highly expressed in testis. Weakly expressed in other tissues.
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for FEM1B blocking peptide

Component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit. Involved in apoptosis by acting as a death receptor-associated protein that mediates apoptosis. Also involved in glucose homeostasis in pancreatic islet. Functions as an adapter/mediator in replication stress-induced signaling that leads to the activation of CHEK1.

NCBI and Uniprot Product Information

• NCBI GI #: 74753369
• NCBI GeneID: 10116
• UniProt Accession #: Q9UK73; O43146
• Molecular Weight: 70,264 Da
• NCBI Official Full Name: Protein fem-1 homolog B
• NCBI Official Synonym Full Names: fem-1 homolog B
• NCBI Official Symbol: FEM1B
• NCBI Official Synonym Symbols: F1AA; F1A-ALPHA; FEM1-beta
• NCBI Protein Information: protein fem-1 homolog B
• UniProt Protein Name: Protein fem-1 homolog B
• UniProt Gene Name: FEM1B
• UniProt Synonym Gene Names: F1AA; KIAA0396; FEM1b; F1A-alpha
• UniProt Entry Name: FEM1B_HUMAN

NCBI Description

This gene encodes an ankyrin repeat protein that belongs to the death receptor-associated family of proteins and plays a role in mediating apoptosis. The encoded protein is also thought to function in the replication stress-induced checkpoint signaling pathway via interaction with checkpoint kinase 1. [provided by RefSeq, Aug 2013]

Uniprot Description

FEM1B: Component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit. Involved in apoptosis by acting as a death receptor-associated protein that mediates apoptosis. Also involved in glucose homeostasis in pancreatic islet. Functions as an adapter/mediator in replication stress-induced signaling that leads to the activation of CHEK1. Belongs to the fem-1 family.

Protein type: Ligase; Cell development/differentiation; Apoptosis; Ubiquitin conjugating system

Chromosomal Location of Human Ortholog: 15q22

Cellular Component: cytoplasm; nucleoplasm; nucleus

Molecular Function: death receptor binding; protein binding; ubiquitin-protein ligase activity

Biological Process: regulation of ubiquitin-protein ligase activity