PLCL1 blocking peptide
PLCL1 Antibody (N-term) Blocking Peptide
Gene Names
PLCL1; PLCE; PLCL; PRIP; PLDL1; PPP1R127
Synonyms
PLCL1; PLCL1 Antibody (N-term) Blocking Peptide; Inactive phospholipase C-like protein 1; PLC-L1; Phospholipase C-deleted in lung carcinoma; Phospholipase C-related but catalytically inactive protein; PRIP; PLCL1 blocking peptide
Specificity
The synthetic peptide sequence used to generate the antibody was selected from the N-term region of human PLCL1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Form/Format
Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
Sequence Length
1095
Cellular Location
Cytoplasm.
Tissue Location
Expressed in a variety of fetal and adult organs including brain, lung and kidney. Its expression was greatly reduced in small and non-small cell lung carcinoma Isoform 1 is predominantly expressed in brain
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
Related Product Information for PLCL1 blocking peptide
Involved in an inositol phospholipid-based intracellular signaling cascade. Shows no PLC activity to phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol. Component in the phospho-dependent endocytosis process of GABA A receptor (By similarity). Regulates the turnover of receptors and thus contributes to the maintenance of GABA-mediated synaptic inhibition. Its aberrant expression could contribute to the genesis and progression of lung carcinoma. Acts as a inhibitor of PPP1C.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
113,012 Da
NCBI Official Full Name
Inactive phospholipase C-like protein 1
NCBI Official Synonym Full Names
phospholipase C like 1
NCBI Official Symbol
PLCL1
NCBI Official Synonym Symbols
PLCE; PLCL; PRIP; PLDL1; PPP1R127
NCBI Protein Information
inactive phospholipase C-like protein 1
UniProt Protein Name
Inactive phospholipase C-like protein 1
Protein Family
UniProt Gene Name
PLCL1
UniProt Synonym Gene Names
PLC-L1; PRIP
UniProt Entry Name
PLCL1_HUMAN
Uniprot Description
PLCL1: a protein closely related to phospholipase C-d1 (PLC-d1) but catalytically inactive. First identified as a novel inositol 1,4,5-trisphosphate binding protein. Has a number of binding partners including protein phosphatase (PP1 and 2A), GABA(A) receptor associated protein, and the beta subunits of GABA(A) receptors, in addition to inositol 1,4,5-trisphosphate. Plays an important role in controlling the dynamics of GABA(A) receptor phosphorylation through PP1 binding and, therefore, the efficacy of synaptic inhibition mediated by these receptors.
Protein type: Phospholipase
Chromosomal Location of Human Ortholog: 2q33
Molecular Function: phospholipase C activity
Research Articles on PLCL1
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Product Notes
The PLCL1 plcl1 (Catalog #AAA9227886) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "PLCL1, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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