NEK7 blocking peptide

NEK7 Antibody (N-term) Blocking Peptide

• Synonyms: NEK7; NEK7 Antibody (N-term) Blocking Peptide; Serine/threonine-protein kinase Nek7; Never in mitosis A-related kinase 7; NimA-related protein kinase 7; NEK7 blocking peptide

• Specificity: The synthetic peptide sequence used to generate the antibody was selected from the N-term region of human NEK7. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
• Form/Format: The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
• Sequence Length: 302

• Cellular Location: Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, spindle pole. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note: Present at centrosome throughout the cell cycle. Also detected at spindle midzone of the anaphase cells and eventually concentrates at the midbody
• Tissue Location: Highly expressed in lung, muscle, testis, brain, heart, liver, leukocyte and spleen. Lower expression in ovary, prostate and kidney. No expression seen in small intestine
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for NEK7 blocking peptide

Protein kinase which plays an important role in mitotic cell cycle progression. Required for microtubule nucleation activity of the centrosome, robust mitotic spindle formation and cytokinesis. Phosphorylates RPS6KB1.

NCBI and Uniprot Product Information

• NCBI GI #: 37537965
• NCBI GeneID: 140609
• UniProt Accession #: Q8TDX7; A6NGT8
• Molecular Weight: 13,402 Da
• NCBI Official Full Name: Serine/threonine-protein kinase Nek7
• NCBI Official Synonym Full Names: NIMA related kinase 7
• NCBI Official Symbol: NEK7
• NCBI Protein Information: serine/threonine-protein kinase Nek7
• UniProt Protein Name: Serine/threonine-protein kinase Nek7
• Protein Family: Serine/threonine-protein kinase
• UniProt Gene Name: NEK7
• UniProt Synonym Gene Names: NimA-related protein kinase 7
• UniProt Entry Name: NEK7_HUMAN

NCBI Description

NIMA-related kinases share high amino acid sequence identity with the gene product of the Aspergillus nidulans 'never in mitosis A' gene, which controls initiation of mitosis.[supplied by OMIM, Jul 2002]

Uniprot Description

NEK7: a protein kinase of the NEK family. Phosphorylates and activates p70S6 kinase.

Protein type: Kinase, protein; EC 2.7.11.1; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Other group; NEK family

Chromosomal Location of Human Ortholog: 1q31.3

Cellular Component: nucleoplasm

Molecular Function: protein serine/threonine kinase activity

Biological Process: cytokinesis; positive regulation of telomerase activity; positive regulation of telomere maintenance via telomerase; protein amino acid phosphorylation; regulation of mitotic cell cycle; spindle assembly