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Centromere Protein H Recombinant Protein | CENPH recombinant protein
Recombinant Centromere Protein H (CENPH)
Source: Prokaryotic expression
MGSSHHHHHH SSGLVPRGSH MASMTGGQQM GRGS- ERI EDRISLLLRL RAQTKQQLLE YKSMIDTNEE KTPEQIMQEK QIEVKIEELE NEIEDVKSNI EMKSLALSRM KLSVALRDNM ENMGPENCVL TDDMKHILKL QKLIMKSQEE SSELEKKLLD VRKKRLQLKQ ASRSKLLEIQ IEKNKQKEDV DKMENSEMIK TMKKKLQTEI KITTVVQHTF QGLILASKTN WAEDPALRET VLQLEKDLNT L
Stability Test: The thermal stability is described by the loss rate of the targetprotein. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation andprecipitation were observed. The loss of this protein is less than 5% within the expiration date under appropriate storage condition.
SDS-Page
SDS-Page
NCBI and Uniprot Product Information
NCBI Description
Centromere and kinetochore proteins play a critical role in centromere structure, kinetochore formation, and sister chromatid separation. The protein encoded by this gene colocalizes with inner kinetochore plate proteins CENP-A and CENP-C in both interphase and metaphase. It localizes outside of centromeric heterochromatin, where CENP-B is localized, and inside the kinetochore corona, where CENP-E is localized during prometaphase. It is thought that this protein can bind to itself, as well as to CENP-A, CENP-B or CENP-C. Multimers of the protein localize constitutively to the inner kinetochore plate and play an important role in the organization and function of the active centromere-kinetochore complex. [provided by RefSeq, Jul 2008]
Uniprot Description
CENPH: Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Required for chromosome congression and efficiently align the chromosomes on a metaphase plate. Belongs to the centromere protein H family.
Protein type: Cell cycle regulation
Chromosomal Location of Human Ortholog: 5p15.2
Cellular Component: kinetochore; nucleoplasm; nucleus; cytosol
Molecular Function: kinetochore binding; protein binding
Biological Process: nucleosome assembly; kinetochore assembly; DNA replication-independent nucleosome assembly at centromere; mitotic cell cycle; kinetochore organization and biogenesis
Research Articles on CENPH
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Product Notes
The CENPH cenph (Catalog #AAA2031069) is a Recombinant Protein produced from Host: E Coli Source: Prokaryotic expression and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's Centromere Protein H can be used in a range of immunoassay formats including, but not limited to, SDS-PAGE, Western Blot (WB), ELISA (EIA), Immunoprecipitation (IP). Researchers should empirically determine the suitability of the CENPH cenph for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: The target protein is fused with two N-terminal Tags, His-tag and T7-tag, its sequence is listed below.MGSSHHHHH H SSGLVPRGSH MASMTGGQQM GRGS- ERI EDRISLLLRL RAQTKQQLLE YKSMIDTNEE KTPEQIMQEK QIEVKIEELE NEIEDVKSNI EMKSLALSRM KLSVALRDNM ENMGPENCVL TDDMKHILKL QKLIMKSQEE SSELEKKLLD VRKKRLQLKQ ASRSKLLEIQ IEKNKQKEDV DKMENSEMIK TMKKKLQTEI KITTVVQHTF QGLILASKTN WAEDPALRET VLQLEKDLNT L
Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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