ITIH2 blocking peptide

ITIH2 Antibody (C-term) Blocking Peptide

• Gene Names: ITIH2; H2P; SHAP
• Synonyms: ITIH2; ITIH2 Antibody (C-term) Blocking Peptide; Inter-alpha-trypsin inhibitor heavy chain H2; ITI heavy chain H2; ITI-HC2; Inter-alpha-inhibitor heavy chain 2; Inter-alpha-trypsin inhibitor complex component II; Serum-derived hyaluronan-associated protein; SHAP; IGHEP2; ITIH2 blocking peptide

• Specificity: The synthetic peptide sequence used to generate the antibody was selected from the C-term region of human ITIH2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 946

• Cellular Location: Secreted.
• Tissue Location: Plasma.
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for ITIH2 blocking peptide

May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes.

NCBI and Uniprot Product Information

• NCBI GI #: 229462889
• NCBI GeneID: 3698
• UniProt Accession #: P19823; Q14659; Q15484; Q5T986
• Molecular Weight: 106,463 Da
• NCBI Official Full Name: Inter-alpha-trypsin inhibitor heavy chain H2
• NCBI Official Synonym Full Names: inter-alpha-trypsin inhibitor heavy chain 2
• NCBI Official Symbol: ITIH2
• NCBI Official Synonym Symbols: H2P; SHAP
• NCBI Protein Information: inter-alpha-trypsin inhibitor heavy chain H2
• UniProt Protein Name: Inter-alpha-trypsin inhibitor heavy chain H2
• Protein Family: Inter-alpha-trypsin inhibitor
• UniProt Gene Name: ITIH2
• UniProt Synonym Gene Names: IGHEP2; ITI heavy chain H2; ITI-HC2; Inter-alpha-inhibitor heavy chain 2; SHAP
• UniProt Entry Name: ITIH2_HUMAN

NCBI Description

The inter-alpha-trypsin inhibitors (ITI) are a family of structurally related plasma serine protease inhibitors involved in extracellular matrix stabilization and in prevention of tumor metastasis. The ITI family contains multiple proteins made up of a light chain (see MIM 176870) and a variable number of heavy chains (Salier et al., 1987 [PubMed 2446322]; Himmelfarb et al., 2004 [PubMed 14744536]).[supplied by OMIM, Nov 2009]

Uniprot Description

ITIH2: May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes. Belongs to the ITIH family.

Protein type: Secreted, signal peptide; Secreted; Inhibitor

Chromosomal Location of Human Ortholog: 10p15

Molecular Function: endopeptidase inhibitor activity