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ENPP6 blocking peptide

ENPP6 Antibody (Center) Blocking peptide

Gene Names
ENPP6; NPP6
Synonyms
ENPP6; ENPP6 Antibody (Center) Blocking peptide; Ectonucleotide pyrophosphatase/phosphodiesterase family member 6; E-NPP 6; NPP-6; 314-; Choline-specific glycerophosphodiester phosphodiesterase; Glycerophosphocholine cholinephosphodiesterase; GPC-Cpde; ENPP6 blocking peptide
Ordering
Form/Format
Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
Sequence Length
440
Cellular Location
Cell membrane; Lipid-anchor, GPI-anchor. Note: A small amount of the protein may be found in the extracellular milieu
Tissue Location
Predominantly expressed in kidney and brain. In the kidney, expressed specifically in the proximal tubules and thin descending limbs of Henle (at protein level)
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
Related Product Information for ENPP6 blocking peptide
Choline-specific glycerophosphodiester phosphodiesterase. The preferred substrate may be lysosphingomyelin (By similarity). Hydrolyzes lysophosphatidylcholine (LPC) to form monoacylglycerol and phosphorylcholine but not lysophosphatidic acid, showing it has a lysophospholipase C activity. Has a preference for LPC with short (12:0 and 14:0) or polyunsaturated (18:2 and 20:4) fatty acids. Also hydrolyzes glycerophosphorylcholine and sphingosylphosphorylcholine efficiently. Hydrolyzes the classical substrate for phospholipase C, p-nitrophenyl phosphorylcholine in vitro, while it does not hydrolyze the classical nucleotide phosphodiesterase substrate, p-nitrophenyl thymidine 5'- monophosphate. Does not hydrolyze diacyl phospholipids such as phosphatidylethanolamine, phosphatidylinositol, phosphatidylserine, phosphatidylglycerol and phosphatidic acid.

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
UniProt Accession #
Molecular Weight
50,241 Da
NCBI Official Full Name
Ectonucleotide pyrophosphatase/phosphodiesterase family member 6
NCBI Official Synonym Full Names
ectonucleotide pyrophosphatase/phosphodiesterase 6
NCBI Official Symbol
ENPP6
NCBI Official Synonym Symbols
NPP6
NCBI Protein Information
ectonucleotide pyrophosphatase/phosphodiesterase family member 6
UniProt Protein Name
Ectonucleotide pyrophosphatase/phosphodiesterase family member 6
UniProt Gene Name
ENPP6
UniProt Synonym Gene Names
E-NPP 6; NPP-6; GPC-Cpde
UniProt Entry Name
ENPP6_HUMAN

Uniprot Description

ENPP6: Choline-specific glycerophosphodiester phosphodiesterase. Hydrolyzes lysophosphatidylcholine (LPC) to form monoacylglycerol and phosphorylcholine but not lysophosphatidic acid, showing it has a lysophospholipase C activity. Has a preference for LPC with short (12:0 and 14:0) or polyunsaturated (18:2 and 20:4) fatty acids. Also hydrolyzes glycerophosphorylcholine and sphingosylphosphorylcholine efficiently. Hydrolyzes the classical substrate for phospholipase C, p-nitrophenyl phosphorylcholine in vitro, while it does not hydrolyze the classical nucleotide phosphodiesterase substrate, p- nitrophenyl thymidine 5'-monophosphate. Does not hydrolyze diacyl phospholipids such as phosphatidylethanolamine, phosphatidylinositol, phosphatidylserine, phosphatidylglycerol and phosphatidic acid. Belongs to the nucleotide pyrophosphatase/phosphodiesterase family.

Protein type: Membrane protein, integral; Lipid Metabolism - ether lipid; Motility/polarity/chemotaxis; Membrane protein, GPI anchor; EC 3.1.4.38; Phosphodiesterase

Chromosomal Location of Human Ortholog: 4q35.1

Cellular Component: extracellular region; plasma membrane

Molecular Function: glycerophosphocholine cholinephosphodiesterase activity; phosphoric diester hydrolase activity

Biological Process: choline metabolic process; glycerophospholipid catabolic process; lipid metabolic process

Research Articles on ENPP6

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Product Notes

The ENPP6 enpp6 (Catalog #AAA9225561) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "ENPP6, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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