TRAIP blocking peptide

TRAIP Antibody (C-term) Blocking Peptide

• Gene Names: TRAIP; TRIP; SCKL9; RNF206
• Synonyms: TRAIP; TRAIP Antibody (C-term) Blocking Peptide; E3 ubiquitin-protein ligase TRAIP; 632-; RING finger protein 206; TRAF-interacting protein; RNF206; TRIP; TRAIP blocking peptide

• Specificity: The synthetic peptide sequence used to generate the antibody was selected from the C-term region of human TRAIP. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 469

• Cellular Location: Cytoplasm. Cytoplasm, perinuclear region. Nucleus, nucleolus. Note: Occasionally observed at nuclear puncta
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for TRAIP blocking peptide

Inhibits activation of NF-kappa-B mediated by TNF (By similarity). Negatively regulates TLR3/4- and RIG-I-mediated IRF3 activation and subsequent IFN-beta production and cellular antiviral response by promoting 'Lys-48'-linked polyubiquitination of TNK1 leading to its proteasomal degradation. May mediate assembly of 'Lys-63'-linked poly-ubiquitin chains on the Y-family polymerase POLN to facilitate bypass of DNA lesions and preserve genomic integrity.

NCBI and Uniprot Product Information

• NCBI GI #: 30580637
• NCBI GeneID: 10293
• UniProt Accession #: Q9BWF2; O00467; B5BU84; B5BUL3
• Molecular Weight: 53,294 Da
• NCBI Official Full Name: E3 ubiquitin-protein ligase TRAIP
• NCBI Official Synonym Full Names: TRAF interacting protein
• NCBI Official Symbol: TRAIP
• NCBI Official Synonym Symbols: TRIP; SCKL9; RNF206
• NCBI Protein Information: E3 ubiquitin-protein ligase TRAIP
• UniProt Protein Name: E3 ubiquitin-protein ligase TRAIP
• Protein Family: E3 ubiquitin-protein ligase
• UniProt Gene Name: TRAIP
• UniProt Synonym Gene Names: RNF206; TRIP
• UniProt Entry Name: TRAIP_HUMAN

NCBI Description

This gene encodes a protein that contains an N-terminal RING finger motif and a putative coiled-coil domain. A similar murine protein interacts with TNFR-associated factor 1 (TRAF1), TNFR-associated factor 2 (TRAF2), and cylindromatosis. The interaction with TRAF2 inhibits TRAF2-mediated nuclear factor kappa-B, subunit 1 activation that is required for cell activation and protection against apoptosis. [provided by RefSeq, Jul 2008]

Uniprot Description

TRAIP: Inhibits activation of NF-kappa-B mediated by TNF.

Protein type: Ubiquitin conjugating system; Nucleolus; Ligase; Ubiquitin ligase; EC 6.3.2.-

Chromosomal Location of Human Ortholog: 3p21.31

Molecular Function: protein binding

Biological Process: apoptosis; cell proliferation; signal transduction