ZW10 blocking peptide

ZW10 Antibody (N-term) Blocking Peptide

• Gene Names: ZW10; HZW10; KNTC1AP
• Synonyms: ZW10; ZW10 Antibody (N-term) Blocking Peptide; Centromere/kinetochore protein zw10 homolog; ZW10 blocking peptide

• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 779

• Cellular Location: Cytoplasm. Endoplasmic reticulum membrane; Peripheral membrane protein. Chromosome, centromere, kinetochore Cytoplasm, cytoskeleton, spindle. Note: Dynamic pattern of localization during the cell cycle. In most cells at interphase, present diffusely in the cytoplasm. In prometaphase, associated with the kinetochore. At metaphase, detected both at the kinetochores and, most prominently, at the spindle, particularly at the spindle poles. In very early anaphase, detected on segregating kinetochores. In late anaphase and telophase, accumulates at the spindle midzone
• Tissue Location: Widely expressed.
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for ZW10 blocking peptide

Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Involved in regulation of membrane traffic between the Golgi and the endoplasmic reticulum.

NCBI and Uniprot Product Information

• NCBI GI #: 11387251
• NCBI GeneID: 9183
• UniProt Accession #: O43264; A1A528
• Molecular Weight: 76,807 Da
• NCBI Official Full Name: Centromere/kinetochore protein zw10 homolog
• NCBI Official Synonym Full Names: zw10 kinetochore protein
• NCBI Official Symbol: ZW10
• NCBI Official Synonym Symbols: HZW10; KNTC1AP
• NCBI Protein Information: centromere/kinetochore protein zw10 homolog
• UniProt Protein Name: Centromere/kinetochore protein zw10 homolog
• Protein Family: ZW10 interactor
• UniProt Gene Name: ZW10
• UniProt Entry Name: ZW10_HUMAN

NCBI Description

This gene encodes a protein that is one of many involved in mechanisms to ensure proper chromosome segregation during cell division. This protein is an essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. [provided by RefSeq, Aug 2011]

Uniprot Description

ZW10: Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Involved in regulation of membrane traffic between the Golgi and the endoplasmic reticulum. Belongs to the ZW10 family.

Protein type: Cell cycle regulation

Chromosomal Location of Human Ortholog: 11q23.2

Cellular Component: cytoplasm; cytosol; endoplasmic reticulum; kinetochore; kinetochore microtubule; membrane; nucleus; spindle pole

Molecular Function: centromeric DNA binding; protein binding

Biological Process: ER to Golgi vesicle-mediated transport; establishment of mitotic spindle orientation; Golgi organization and biogenesis; meiosis; mitotic cell cycle checkpoint; mitotic cell cycle spindle assembly checkpoint; mitotic metaphase plate congression; mitotic sister chromatid segregation; protein complex assembly; regulation of exit from mitosis; retrograde vesicle-mediated transport, Golgi to ER; sister chromatid cohesion