XRN2 blocking peptide

XRN2 Antibody (N-term) Blocking Peptide

• Synonyms: XRN2; XRN2 Antibody (N-term) Blocking Peptide; 5'-3' exoribonuclease 2; 3113-; DHM1-like protein; DHP protein; XRN2 blocking peptide

• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 950

• Cellular Location: Nucleus, nucleolus
• Tissue Location: Expressed in the spleen, thymus, prostate, testis, ovary, small intestine, colon, peripheral blood leukocytes, heart, brain, placenta, lung, liver, skeletal muscle, kidney, and pancreas. Isoform 2 is expressed predominantly in peripheral blood leukocytes.
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for XRN2 blocking peptide

Possesses 5'->3' exoribonuclease activity (By similarity). May promote the termination of transcription by RNA polymerase II. During transcription termination, cleavage at the polyadenylation site liberates a 5' fragment which is subsequently processed to form the mature mRNA and a 3' fragment which remains attached to the elongating polymerase. The processive degradation of this 3' fragment by this protein may promote termination of transcription.

NCBI and Uniprot Product Information

• NCBI GI #: 30173484
• NCBI GeneID: 22803
• UniProt Accession #: Q9H0D6; Q3L8N4; Q6KGZ9; Q9BQL1; Q9NTW0; Q9NXS6; Q9UL53
• Molecular Weight: 99,962 Da
• NCBI Official Full Name: 5'-3' exoribonuclease 2
• NCBI Official Synonym Full Names: 5'-3' exoribonuclease 2
• NCBI Official Symbol: XRN2
• NCBI Protein Information: 5'-3' exoribonuclease 2
• UniProt Protein Name: 5'-3' exoribonuclease 2
• UniProt Gene Name: XRN2
• UniProt Synonym Gene Names: DHP protein
• UniProt Entry Name: XRN2_HUMAN

NCBI Description

This gene encodes a 5'-3' exonuclease that promotes transcription termination at cotranscriptional cleavage sites. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]

Uniprot Description

XRN2: Possesses 5'->3' exoribonuclease activity. May promote the termination of transcription by RNA polymerase II. During transcription termination, cleavage at the polyadenylation site liberates a 5' fragment which is subsequently processed to form the mature mRNA and a 3' fragment which remains attached to the elongating polymerase. The processive degradation of this 3' fragment by this protein may promote termination of transcription. Belongs to the 5'-3' exonuclease family. XRN2/RAT1 subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.1.13.-; Nucleolus; Ribonuclease; RNA processing; RNA-binding; Cell development/differentiation

Chromosomal Location of Human Ortholog: 20p11.2-p11.1

Cellular Component: membrane; nucleolus; nucleoplasm; nucleus

Molecular Function: 3'-5'-exoribonuclease activity; 5'-3' exonuclease activity; 5'-3' exoribonuclease activity; nuclease activity; protein binding

Biological Process: cell growth; DNA catabolic process, exonucleolytic; RNA catabolic process; RNA metabolic process; RNA processing; rRNA processing; spermatogenesis