BID (S61) Blocking Peptide | Bid blocking peptide

mouse BID Antibody (S61) Blocking Peptide

• Gene Names: Bid; AI875481; AU022477; 2700049M22Rik
• Synonyms: BID (S61); mouse BID Antibody (S61) Blocking Peptide; BH3-interacting domain death agonist; p22 BID; BID; BH3-interacting domain death agonist p15; p15 BID; BH3-interacting domain death agonist p13; p13 BID; BH3-interacting domain death agonist p11; p11 BID; Bid; Bid blocking peptide

• Specificity: The synthetic peptide sequence used to generate the antibody was selected from the S61 region of human mouse BID. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 195

• Cellular Location: Cytoplasm. Mitochondrion membrane. Note: When uncleaved, it is predominantly cytoplasmic. p15 BID translocates to mitochondria as an integral membrane protein. p13 and p22 BID are associated with the mitochondrial membrane
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for Bid blocking peptide

Induces caspases and apoptosis. Counters the protective effect of Bcl-2. The major proteolytic product p15 BID allows the release of cytochrome c.

NCBI and Uniprot Product Information

• NCBI GI #: 31542228
• NCBI GeneID: 12122
• NCBI Accession #: NP_031570
• NCBI GenBank Nucleotide #: NM_007544.3
• UniProt Accession #: P70444; Q99M39
• Molecular Weight: 21,952 Da
• NCBI Official Full Name: BH3-interacting domain death agonist
• NCBI Official Synonym Full Names: BH3 interacting domain death agonist
• NCBI Official Symbol: Bid
• NCBI Official Synonym Symbols: AI875481; AU022477; 2700049M22Rik
• NCBI Protein Information: BH3-interacting domain death agonist
• UniProt Protein Name: BH3-interacting domain death agonist
• Protein Family: BH3-interacting domain death agonist
• UniProt Gene Name: Bid
• UniProt Synonym Gene Names: BID
• UniProt Entry Name: BID_MOUSE

Uniprot Description

BID: a pro-apoptotic member of the Bcl-2 superfamily. Targets intracellular membranes and contains a BH3 death domain. Heterodimerizes with either the pro-apoptotic protein BAX or the anti-apoptotic protein BCL2, antagonizing its protective effect. The activity of BID is regulated by Caspase 8-mediated cleavage, exposing the BH3 domain and significantly changing the surface charge and hydrophobicity, causing translocation to mitochondria where it triggers cytochrome c release. Multiple alternatively spliced variants have been found.

Protein type: Mitochondrial; Apoptosis

Cellular Component: cytoplasm; cytosol; membrane; mitochondrion

Molecular Function: protein binding; ubiquitin protein ligase binding

Biological Process: apoptotic mitochondrial changes; caspase activation; DNA damage response, signal transduction; positive regulation of apoptosis; positive regulation of protein homooligomerization; positive regulation of protein oligomerization; protein homooligomerization; protein targeting to mitochondrion; regulation of cell proliferation; regulation of protein oligomerization; release of cytochrome c from mitochondria