MAML1 Blocking Peptide | MAML1 (HGNC:13632) blocking peptide
MAML1 Antibody (Center) Blocking peptide
NCBI and Uniprot Product Information
NCBI Description
This protein is the human homolog of mastermind, a Drosophila protein that plays a role in the Notch signaling pathway involved in cell-fate determination. There is in vitro evidence that the human homolog forms a complex with the intracellular portion of human Notch receptors and can increase expression of a Notch-induced gene. This evidence supports its proposed function as a transcriptional co-activator in the Notch signaling pathway. [provided by RefSeq, Jul 2008]
Uniprot Description
MAML1: Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Enhances phosphorylation and proteolytic turnover of the NOTCH intracellular domain in the nucleus through interaction with CDK8. Binds to CREBBP/CBP which promotes nucleosome acetylation at NOTCH enhancers and activates transcription. Induces phosphorylation and localization of CREBBP to nuclear foci. Plays a role in hematopoietic development by regulating NOTCH-mediated lymphoid cell fate decisions. Interacts (via N-terminus) with NOTCH1, NOTCH2, NOTCH3 and NOTCH4 (via ankyrin repeat region). Interacts (via N-terminus) with p53 (via DNA-binding region). Forms a DNA-binding complex with Notch proteins and RBPSUH/RBP-J kappa/CBF1. Also binds CREBBP/CBP and CDK8. Widely expressed with highest levels in heart, pancreas, peripheral blood leukocytes and spleen. Belongs to the mastermind family.
Protein type: Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 5q35
Cellular Component: intracellular membrane-bound organelle; nucleoplasm; nucleus
Molecular Function: peptide antigen binding; protein binding; protein kinase binding; transcription coactivator activity
Biological Process: activation of Notch receptor target transcription factor; Notch signaling pathway; positive regulation of transcription from RNA polymerase II promoter; protein amino acid phosphorylation; transcription initiation from RNA polymerase II promoter
Research Articles on MAML1 (HGNC:13632)
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Product Notes
The MAML1 (HGNC:13632) maml1 (Catalog #AAA9218471) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "MAML1, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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