Rabbit anti-Human FGF5 Polyclonal Antibody | anti-FGF5 antibody

FGF5 Antibody (N-Term)

Cat. Num. AAA9216618

• Gene Names: FGF5; HBGF-5; TCMGLY; Smag-82
• Reactivity: Human
• Applications: Western Blot
• Synonyms: FGF5; Polyclonal Antibody; FGF5 Antibody (N-Term); Purified Rabbit Polyclonal Antibody (Pab); Fibroblast growth factor 5; FGF-5; Heparin-binding growth factor 5; HBGF-5; Smag-82; anti-FGF5 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: Ig
• Specificity: This FGF5 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 140-172 amino acids from human FGF5.
• Form/Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
• Sequence Length: 268

• Applicable Applications for anti-FGF5 antibody: Western Blot (WB)
• Application Notes: WB ~~ 1:2000
• Antigen Source: Human
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Western Blot (WB)

(All lanes : Anti-FGF5 Antibody (N-Term) at 1:2000 dilutionLane 1: A375 whole cell lysateLane 2: human placenta lysateLane 3: Hela whole cell lysateLysates/proteins at 20 ug per lane.SecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution.Predicted band size : 30 kDaBlocking/Dilution buffer: 5% NFDM/TBST.)

Related Product Information for anti-FGF5 antibody

Plays an important role in the regulation of cell proliferation and cell differentiation. Required for normal regulation of the hair growth cycle. Functions as an inhibitor of hair elongation by promoting progression from anagen, the growth phase of the hair follicle, into catagen the apoptosis-induced regression phase (By similarity).

Product Categories/Family for anti-FGF5 antibody

Cancer; Cardiovascular; Signal transduction

References

Haub O.,et al.Proc. Natl. Acad. Sci. U.S.A. 87:8022-8026(1990). Zhan X.,et al.Mol. Cell. Biol. 8:3487-3495(1988). Ozawa K.,et al.Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases. de Vries C.J.M.,et al.J. Biol. Chem. 275:23939-23947(2000). Hanada K.-I.,et al.Cancer Res. 61:5511-5516(2001).

NCBI and Uniprot Product Information

• NCBI GI #: 73486655
• NCBI GeneID: 2250
• NCBI Accession #: NP_004455.2
• NCBI GenBank Nucleotide #: NM_004464.3
• UniProt Accession #: P12034; O75846; Q3Y8M3; Q8NF90; B2R554
• Molecular Weight: 29551
• NCBI Official Full Name: fibroblast growth factor 5 isoform 1
• NCBI Official Synonym Full Names: fibroblast growth factor 5
• NCBI Official Symbol: FGF5
• NCBI Official Synonym Symbols: HBGF-5; TCMGLY; Smag-82
• NCBI Protein Information: fibroblast growth factor 5
• UniProt Protein Name: Fibroblast growth factor 5
• Protein Family: Fibroblast growth factor
• UniProt Gene Name: FGF5
• UniProt Synonym Gene Names: FGF-5; HBGF-5
• UniProt Entry Name: FGF5_HUMAN

NCBI Description

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was identified as an oncogene, which confers transforming potential when transfected into mammalian cells. Targeted disruption of the homolog of this gene in mouse resulted in the phenotype of abnormally long hair, which suggested a function as an inhibitor of hair elongation. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Uniprot Description

FGF5: Plays an important role in the regulation of cell proliferation and cell differentiation. Required for normal regulation of the hair growth cycle. Functions as an inhibitor of hair elongation by promoting progression from anagen, the growth phase of the hair follicle, into catagen the apoptosis-induced regression phase. Belongs to the heparin-binding growth factors family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Cytokine; Oncoprotein; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 4q21

Cellular Component: extracellular space; extracellular region; intracellular

Molecular Function: growth factor activity; fibroblast growth factor receptor binding

Biological Process: epidermal growth factor receptor signaling pathway; axon guidance; nervous system development; phosphoinositide-mediated signaling; fibroblast growth factor receptor signaling pathway; activation of MAPKK activity; nerve growth factor receptor signaling pathway; MAPKKK cascade; cell proliferation; glial cell differentiation; cell-cell signaling; positive regulation of cell division; small GTPase mediated signal transduction; positive regulation of cell proliferation; Ras protein signal transduction; insulin receptor signaling pathway; innate immune response; vascular endothelial growth factor receptor signaling pathway

Disease: Trichomegaly