Mouse anti-Human CaMKIV Monoclonal Antibody | anti-CAMK4 antibody

CaMKIV Antibody

Cat. Num. AAA9215584

• Gene Names: CAMK4; IV; caMK; CaMK IV; CaMK-GR
• Reactivity: Human
• Applications: Western Blot
• Synonyms: CaMKIV; Monoclonal Antibody; CaMKIV Antibody; Purified Mouse Monoclonal Antibody (Mab); Brain Ca(2) calmodulin dependent protein kinase type 4; Brain Ca(2) calmodulin dependent protein kinase type IV; Brain Ca -calmodulin dependent protein kinase type IV; Calcium / calmodulin dependent protein kinase type 4 catalytic chain; Calcium / calmodulin dependent protein kinase type IV catalytic chain; Calcium/calmodulin dependent protein kinase IV; Calcium/calmodulin dependent protein kinase type IV; Calcium/calmodulin-dependent protein kinase type IV; CAM kinase 4; CAM kinase GR; CAM kinase IV; CAM kinase-GR; CaMK 4; CAMK GR; CaMK IV; CaMK4; CaMKGR; IV; KCC4_HUMAN; MGC36771; anti-CAMK4 antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Form/Format: Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50%,glycerol
• Sequence Length: 473

• Applicable Applications for anti-CAMK4 antibody: Western Blot (WB)
• Application Notes: WB ~~ 1:1000
• Antigen Source: Human
• Antigen Type: Recombinant Protein
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Western Blot (WB)

(Western blot detection of CaMKIV in Romas and Jurkat cell lysates using CaMKIV mouse mAb (1:1000 diluted).Predicted band size:52KDa.Observed band size:55KDa.)

Related Product Information for anti-CAMK4 antibody

Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK4 signaling cascade and regulates, mainly by phosphorylation, the activity of several transcription activators, such as CREB1, MEF2D, JUN and RORA, which play pivotal roles in immune response, inflammation, and memory consolidation. In the thymus, regulates the CD4(+)/CD8(+) double positive thymocytes selection threshold during T-cell ontogeny. In CD4 memory T-cells, is required to link T-cell antigen receptor (TCR) signaling to the production of IL2, IFNG and IL4 (through the regulation of CREB and MEF2). Regulates the differentiation and survival phases of osteoclasts and dendritic cells (DCs). Mediates DCs survival by linking TLR4 and the regulation of temporal expression of BCL2. Phosphorylates the transcription activator CREB1 on 'Ser-133' in hippocampal neuron nuclei and contribute to memory consolidation and long term potentiation (LTP) in the hippocampus. Can activate the MAP kinases MAPK1/ERK2, MAPK8/JNK1 and MAPK14/p38 and stimulate transcription through the phosphorylation of ELK1 and ATF2. Can also phosphorylate in vitro CREBBP, PRM2, MEF2A and STMN1/OP18.

Product Categories/Family for anti-CAMK4 antibody

Neuroscience; Signal Transduction

References

Kitani T.,et al.J. Biochem. 115:637-640(1994). Bland M.M.,et al.Gene 142:191-197(1994). Mosialos G.,et al.J. Virol. 68:1697-1705(1994). Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases. Hanissian S.H.,et al.J. Biol. Chem. 268:20055-20063(1993).

NCBI and Uniprot Product Information

• NCBI GI #: 4502557
• NCBI GeneID: 814
• NCBI Accession #: NP_001735.1
• NCBI GenBank Nucleotide #: NM_001744.4
• UniProt Accession #: Q16566; D3DSZ7
• Molecular Weight: 51926
• NCBI Official Full Name: calcium/calmodulin-dependent protein kinase type IV
• NCBI Official Synonym Full Names: calcium/calmodulin-dependent protein kinase IV
• NCBI Official Symbol: CAMK4
• NCBI Official Synonym Symbols: IV; caMK; CaMK IV; CaMK-GR
• NCBI Protein Information: calcium/calmodulin-dependent protein kinase type IV
• UniProt Protein Name: Calcium/calmodulin-dependent protein kinase type IV
• Protein Family: Calcium/calmodulin-dependent protein kinase
• UniProt Gene Name: CAMK4
• UniProt Synonym Gene Names: CAMK; CAMK-GR; CAMKIV; CaMK IV
• UniProt Entry Name: KCC4_HUMAN

NCBI Description

The product of this gene belongs to the serine/threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. This enzyme is a multifunctional serine/threonine protein kinase with limited tissue distribution, that has been implicated in transcriptional regulation in lymphocytes, neurons and male germ cells. [provided by RefSeq, Jul 2008]

Uniprot Description

CAMK4: a protein kinase of the CAMK1 family. Implicated in transcriptional regulation in lymphocytes, neurons and male germ cells. Two alternatively sliced isoforms have been described.

Protein type: EC 2.7.11.17; Protein kinase, CAMK; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); CAMK group; CAMK1 family

Chromosomal Location of Human Ortholog: 5q21.3

Cellular Component: nucleoplasm; cytoplasm; nucleolus; cytosol

Molecular Function: calmodulin binding; calcium-dependent protein serine/threonine kinase activity; calmodulin-dependent protein kinase activity; ATP binding

Biological Process: epidermal growth factor receptor signaling pathway; adaptive immune response; fibroblast growth factor receptor signaling pathway; nerve growth factor receptor signaling pathway; protein amino acid autophosphorylation; regulation of T cell differentiation in the thymus; positive regulation of transcription, DNA-dependent; myeloid dendritic cell differentiation; nucleocytoplasmic transport; signal transduction; protein amino acid phosphorylation; positive regulation of protein export from nucleus; synaptic transmission; peptidyl-serine phosphorylation; regulation of osteoclast differentiation; long-term memory; phospholipase C activation; innate immune response; nerve-nerve synaptic transmission; inflammatory response; myeloid dendritic cell cytokine production