Western Blot (WB)
(KCNA4 Antibody (C-term) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the KCNA4 antibody detected the KCNA4 protein (arrow).)
Rabbit KCNA4 Polyclonal Antibody | anti-KCNA4 antibody
KCNA4 Antibody (C-term)
Western Blot (WB)
(KCNA4 Antibody (C-term) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the KCNA4 antibody detected the KCNA4 protein (arrow).)
Western Blot (WB)
(KCNA4 Antibody (C-term) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the KCNA4 antibody detected the KCNA4 protein (arrow).)
voltage-gated ion channels from both functional and structural
standpoints. Their diverse functions include regulating
neurotransmitter release, heart rate, insulin secretion, neuronal
excitability, epithelial electrolyte transport, smooth muscle
contraction, and cell volume. Four sequence-related potassium
channel genes - shaker, shaw, shab, and shal - have been identified
in Drosophila, and each has been shown to have human homolog(s).
This gene encodes a member of the potassium channel, voltage-gated,
shaker-related subfamily. This member contains six
membrane-spanning domains with a shaker-type repeat in the fourth
segment. It belongs to the A-type potassium current class, the
members of which may be important in the regulation of the fast
repolarizing phase of action potentials in heart and thus may
influnce the duration of cardiac action potential. The coding
region of this gene is intronless, and the gene is clustered with
genes KCNA3 and KCNA10 on chromosome 1.
Angelova, P.R., et al. Eur. J. Neurosci. 29(10):1943-1950(2009)
Mckeown, L., et al. J. Biol. Chem. 283(44):30421-30432(2008)
Lee, J.H., et al. Mol. Pharmacol. 73(3):619-626(2008)
Gessler, M., et al. Hum. Genet. 90(3):319-321(1992)
NCBI and Uniprot Product Information
NCBI Description
Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the A-type potassium current class, the members of which may be important in the regulation of the fast repolarizing phase of action potentials in heart and thus may influence the duration of cardiac action potential.[provided by RefSeq, Mar 2011]
Uniprot Description
Kv1.4: Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.4/KCNA4 sub-subfamily.
Protein type: Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 11p14
Cellular Component: voltage-gated potassium channel complex; integral to plasma membrane; axon; plasma membrane; integral to membrane
Molecular Function: potassium ion binding; protein binding; voltage-gated potassium channel activity; delayed rectifier potassium channel activity
Biological Process: synaptic transmission; protein homooligomerization; potassium ion transport
Research Articles on KCNA4
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Product Notes
The KCNA4 kcna4 (Catalog #AAA9212240) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 591-619. The KCNA4 Antibody (C-term) reacts with Human (Predicted Reactivity: Bovine, Mouse, Rat) and may cross-react with other species as described in the data sheet. AAA Biotech's KCNA4 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the KCNA4 kcna4 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "KCNA4, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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