Rabbit anti-Human KCNA4 Polyclonal Antibody | anti-KCNA4 antibody

KCNA4, CT (KCNA4, KCNA4L, Potassium voltage-gated channel subfamily A member 4, HPCN2, Voltage-gated K(+) channel HuKII, Voltage-gated potassium channel HBK4, Voltage-gated potassium channel HK1, Voltage-gated potassium channel subunit Kv1.4) (PE)

Cat. Num. AAA6312246

• Gene Names: KCNA4; HK1; HBK4; PCN2; HPCN2; HUKII; KCNA8; KV1.4; KCNA4L
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: KCNA4; Polyclonal Antibody; CT (KCNA4; KCNA4L; Potassium voltage-gated channel subfamily A member 4; HPCN2; Voltage-gated K(+) channel HuKII; Voltage-gated potassium channel HBK4; Voltage-gated potassium channel HK1; Voltage-gated potassium channel subunit Kv1.4) (PE); Voltage-gated potassium channel subunit Kv1.4; anti-KCNA4 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with R-Phycoerythrin (PE).

• Applicable Applications for anti-KCNA4 antibody: Western Blot (WB), FLISA
• Application Notes: WB: 1:100-500; FLISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: KCNA4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 591-619 amino acids from the C-terminal region of human KCNA4.
• Conjugate: PE
• Note: Preservative Free
• Special Handling: Light sensitive
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: PE conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(KCNA4 Antibody (C-term) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the KCNA4 antibody detected the KCNA4 protein (arrow).)

Related Product Information for anti-KCNA4 antibody

Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes-shaker, shaw, shab, and shal-have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the A-type potassium current class, the members of which may be important in the regulation of the fast repolarizing phase of action potentials in heart and thus may influnce the duration of cardiac action potential. The coding region of this gene is intronless, and the gene is clustered with genes KCNA3 and KCNA10 on chromosome 1.

Product Categories/Family for anti-KCNA4 antibody

Antibodies; Ion Channel

References

Schwetz, T.A., et al. Biochim. Biophys. Acta 1798(3):367-375(2010). Angelova, P.R., et al. Eur. J. Neurosci. 29(10):1943-1950(2009). Mckeown, L., et al. J. Biol. Chem. 283(44):30421-30432(2008). Lee, J.H., et al. Mol. Pharmacol. 73(3):619-626(2008). Gessler, M., et al. Hum. Genet. 90(3):319-321(1992).

NCBI and Uniprot Product Information

• NCBI GI #: 4504817
• NCBI GeneID: 3739
• NCBI Accession #: NP_002224.1
• NCBI GenBank Nucleotide #: NM_002233.3
• UniProt Accession #: P22459
• Molecular Weight: 73,257 Da
• NCBI Official Full Name: potassium voltage-gated channel subfamily A member 4
• NCBI Official Synonym Full Names: potassium voltage-gated channel subfamily A member 4
• NCBI Official Symbol: KCNA4
• NCBI Official Synonym Symbols: HK1; HBK4; PCN2; HPCN2; HUKII; KCNA8; KV1.4; KCNA4L
• NCBI Protein Information: potassium voltage-gated channel subfamily A member 4
• UniProt Protein Name: Potassium voltage-gated channel subfamily A member 4
• Protein Family: Potassium voltage-gated channel subfamily
• UniProt Gene Name: KCNA4
• UniProt Synonym Gene Names: KCNA4L
• UniProt Entry Name: KCNA4_HUMAN

NCBI Description

Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the A-type potassium current class, the members of which may be important in the regulation of the fast repolarizing phase of action potentials in heart and thus may influence the duration of cardiac action potential.[provided by RefSeq, Mar 2011]

Uniprot Description

Kv1.4: Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.4/KCNA4 sub-subfamily.

Protein type: Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 11p14

Cellular Component: voltage-gated potassium channel complex; integral to plasma membrane; axon; plasma membrane; integral to membrane

Molecular Function: potassium ion binding; voltage-gated potassium channel activity; protein binding; delayed rectifier potassium channel activity

Biological Process: synaptic transmission; potassium ion transport; protein homooligomerization