Western Blot (WB)
(TRIM2 Antibody (C-term) western blot analysis in U251 cell line lysates (35ug/lane).This demonstrates the TRIM2 antibody detected the TRIM2 protein (arrow).)
Rabbit TRIM2 Polyclonal Antibody | anti-TRIM2 antibody
TRIM2 Antibody (C-term)
Western Blot (WB)
(TRIM2 Antibody (C-term) western blot analysis in U251 cell line lysates (35ug/lane).This demonstrates the TRIM2 antibody detected the TRIM2 protein (arrow).)
Western Blot (WB)
(TRIM2 Antibody (C-term) western blot analysis in U251 cell line lysates (35ug/lane).This demonstrates the TRIM2 antibody detected the TRIM2 protein (arrow).)
tripartite motif (TRIM) family. The TRIM motif includes three
zinc-binding domains, a RING, a B-box type 1 and a B-box type 2,
and a coiled-coil region. The protein localizes to cytoplasmic
filaments. Its function has not been identified. [provided by
RefSeq].
Ohkawa, N., et al. J. Neurochem. 78(1):75-87(2001)
Reymond, A., et al. EMBO J. 20(9):2140-2151(2001)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic filaments. It plays a neuroprotective role and functions as an E3-ubiquitin ligase in proteasome-mediated degradation of target proteins. Mutations in this gene can cause early-onset axonal neuropathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]
Uniprot Description
TRIM2: UBE2D1-dependent E3 ubiquitin-protein ligase that mediates the ubiquitination of NEFL and of phosphorylated BCL2L11. Plays a neuroprotective function. May play a role in neuronal rapid ischemic tolerance. Belongs to the TRIM/RBCC family.
Protein type: Ubiquitin conjugating system; EC 6.3.2.-; Ubiquitin ligase; Ligase
Chromosomal Location of Human Ortholog: 4q31.3
Cellular Component: cytoplasm
Molecular Function: protein binding; zinc ion binding; ubiquitin-protein ligase activity; ligase activity
Biological Process: regulation of neuron apoptosis; protein ubiquitination
Disease: Charcot-marie-tooth Disease, Axonal, Type 2r
Research Articles on TRIM2
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Product Notes
The TRIM2 trim2 (Catalog #AAA9206969) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 592-621. The TRIM2 Antibody (C-term) reacts with Human (Predicted Reactivity: Bovine, Mouse, Rat) and may cross-react with other species as described in the data sheet. AAA Biotech's TRIM2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the TRIM2 trim2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TRIM2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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