Western Blot (WB)
(TULP3 Antibody (C-term) western blot analysis in NCI-H292 cell line lysates (35ug/lane).This demonstrates the TULP3 antibody detected the TULP3 protein (arrow).)
Rabbit anti-Human TULP3 Polyclonal Antibody | anti-TULP3 antibody
TULP3 Antibody (C-term)
Western Blot (WB)
(TULP3 Antibody (C-term) western blot analysis in NCI-H292 cell line lysates (35ug/lane).This demonstrates the TULP3 antibody detected the TULP3 protein (arrow).)
Western Blot (WB)
(TULP3 Antibody (C-term) western blot analysis in NCI-H292 cell line lysates (35ug/lane).This demonstrates the TULP3 antibody detected the TULP3 protein (arrow).)
bipartite transcription factors. Members of this family have been
identified in plants, vertebrates, and invertebrates, and they
share a conserved N-terminal transcription activation region and a
conserved C-terminal DNA and phosphatidylinositol-phosphate binding
region. The encoded protein binds to phosphoinositides in the
plasma membrane via its C-terminal region and probably functions as
a membrane-bound transcription regulator that translocates to the
nucleus in response to phosphoinositide hydrolysis, for instance,
induced by G-protein-coupled-receptor signaling. It plays an
important role in neuronal development and function. Two transcript
variants encoding distinct isoforms have been identified for this
gene.
Ikeda, A., et al. J. Cell. Sci. 115 (PT 1), 9-14 (2002) :
Santagata, S., et al. Science 292(5524):2041-2050(2001)
Ikeda, S., et al. Invest. Ophthalmol. Vis. Sci. 40(11):2706-2712(1999)
Nishina, P.M., et al. Genomics 54(2):215-220(1998)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the tubby gene family of bipartite transcription factors. Members of this family have been identified in plants, vertebrates, and invertebrates, and they share a conserved N-terminal transcription activation region and a conserved C-terminal DNA and phosphatidylinositol-phosphate binding region. The encoded protein binds to phosphoinositides in the plasma membrane via its C-terminal region and probably functions as a membrane-bound transcription regulator that translocates to the nucleus in response to phosphoinositide hydrolysis, for instance, induced by G-protein-coupled-receptor signaling. It plays an important role in neuronal development and function. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, May 2009]
Uniprot Description
TULP3: Negatively regulates SHH signal transduction. Probably functions in signal transduction from heterotrimeric G protein-coupled receptors. Binds to phosphorylated inositide lipids. Belongs to the TUB family.
Chromosomal Location of Human Ortholog: 12p13.3
Cellular Component: plasma membrane; nucleolus; extracellular region; axoneme; nucleus; cilium
Molecular Function: phosphatidylinositol-4,5-bisphosphate binding; protein binding; enzyme binding; protein complex binding; phosphoinositide binding
Biological Process: anterior/posterior pattern formation; G-protein coupled receptor protein signaling pathway; central nervous system neuron differentiation; regulation of transcription, DNA-dependent; negative regulation of smoothened signaling pathway; neural tube closure; embryonic neurocranium morphogenesis; embryonic digit morphogenesis; brain development; regulation of G-protein coupled receptor protein signaling pathway; embryonic camera-type eye development; negative regulation of smoothened signaling pathway in ventral spinal cord patterning
Research Articles on TULP3
Similar Products
Product Notes
The TULP3 tulp3 (Catalog #AAA9205456) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 374-400. The TULP3 Antibody (C-term) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's TULP3 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the TULP3 tulp3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TULP3, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
