Western Blot (WB)
(VPS11 Antibody (C-term) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the VPS11 antibody detected the VPS11 protein (arrow).)
Rabbit VPS11 Polyclonal Antibody | anti-VPS11 antibody
VPS11 Antibody (C-term)
Western Blot (WB)
(VPS11 Antibody (C-term) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the VPS11 antibody detected the VPS11 protein (arrow).)
Western Blot (WB)
(VPS11 Antibody (C-term) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the VPS11 antibody detected the VPS11 protein (arrow).)
in segregation of intracellular molecules into distinct organelles.
Genetic studies in yeast have identified more than 40 vacuolar
protein sorting (VPS) genes involved in vesicle transport to
vacuoles. This gene encodes the human homolog of yeast class C
Vps11 protein. The mammalian class C Vps proteins are predominantly
associated with late endosomes/lysosomes, and like their yeast
counterparts, may mediate vesicle trafficking steps in the
endosome/lysosome pathway.
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Zhu, G.D., et al. Mol. Biol. Cell 20(4):1223-1240(2009)
Wan, D., et al. Proc. Natl. Acad. Sci. U.S.A. 101(44):15724-15729(2004)
Lehner, B., et al. Genome Res. 14(7):1315-1323(2004)
NCBI and Uniprot Product Information
NCBI Description
Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene encodes the human homolog of yeast class C Vps11 protein. The mammalian class C Vps proteins are predominantly associated with late endosomes/lysosomes, and like their yeast counterparts, may mediate vesicle trafficking steps in the endosome/lysosome pathway. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]
Uniprot Description
VPS11: May play a role in vesicle-mediated protein trafficking to lysosomal compartments and in membrane docking/fusion reactions of late endosomes/lysosomes. Belongs to the VPS11 family.
Protein type: Ubiquitin conjugating system
Chromosomal Location of Human Ortholog: 11q23
Cellular Component: late endosome membrane; endocytic vesicle; lysosome; lysosomal membrane; late endosome; endosome
Molecular Function: protein binding; syntaxin binding; zinc ion binding; nucleotide binding
Biological Process: vesicle-mediated transport; intracellular protein transport
Research Articles on VPS11
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Product Notes
The VPS11 vps11 (Catalog #AAA9203973) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 772-800. The VPS11 Antibody (C-term) reacts with Human (Predicted Reactivity: Mouse) and may cross-react with other species as described in the data sheet. AAA Biotech's VPS11 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the VPS11 vps11 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "VPS11, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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