Mouse anti-Silkworm Cytoplasmic protein NCK1 Monoclonal Antibody | anti-NCK1 antibody

Cytoplasmic protein NCK1 Mouse mAb for Silkworm

Cat. Num. AAA435418

• Gene Names: NCK1; NCK; nck-1; NCKalpha
• Reactivity: Silkworm
• Applications: Western Blot
• Synonyms: Cytoplasmic protein NCK1; Monoclonal Antibody; Cytoplasmic protein NCK1 Mouse mAb for Silkworm; NCK1 Mouse mAb; anti-NCK1 antibody

• Host: Mouse
• Reactivity: Silkworm
• Clonality: Monoclonal
• Isotype: IgG
• Sequence Length: 377

• Applicable Applications for anti-NCK1 antibody: Western Blot (WB)
• Source Note: This monoclonal antibody is produced by immunizing mice with a polypeptide corresponding to cytoplasmic protein NCK1 protein.
• Preparation and Storage: Store at -20 degree C. Stable for one year from the date of shipment.

Western Blot (WB)

(Western blot -Cytoplasmic protein NCK1 Mouse mAb for the larva stage whole body of silkworm)

Related Product Information for anti-NCK1 antibody

This gene is a member of the aldehyde dehydrogenase family and encodes a bifunctional ATP-and NADPH-dependent mitochondrial enzyme with both gamma-glutamyl kinase and gamma-glutamyl phosphate reductase activities. The encoded protein catalyzes the reduction of glutamate to delta1-pyrroline-5-carboxylate, a critical step in the de novo biosynthesis of proline, ornithine and arginine. Mutations in this gene lead to hyperammonemia, hypoornithinemia, hypocitrullinemia, hypoargininemia and hypoprolinemia and may be associated with neurodegeneration, cataracts and connective tissue diseases. Alternatively spliced transcript variants, encoding different isoforms, have been described for this gene.

Product Categories/Family for anti-NCK1 antibody

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NCBI and Uniprot Product Information

• NCBI GI #: 5453754
• NCBI GeneID: 4690
• NCBI Accession #: NP_006144.1
• NCBI GenBank Nucleotide #: NM_006153.5
• UniProt Accession #: P16333; B7Z751; D3DNE3
• Molecular Weight: Predicted MW: 87.2kDa
• NCBI Official Full Name: cytoplasmic protein NCK1 isoform 1
• NCBI Official Synonym Full Names: NCK adaptor protein 1
• NCBI Official Symbol: NCK1
• NCBI Official Synonym Symbols: NCK; nck-1; NCKalpha
• NCBI Protein Information: cytoplasmic protein NCK1
• UniProt Protein Name: Cytoplasmic protein NCK1
• Protein Family: Cytoplasmic protein
• UniProt Gene Name: NCK1
• UniProt Synonym Gene Names: NCK; Nck-1

NCBI Description

The protein encoded by this gene is one of the signaling and transforming proteins containing Src homology 2 and 3 (SH2 and SH3) domains. It is located in the cytoplasm and is an adaptor protein involved in transducing signals from receptor tyrosine kinases to downstream signal recipients such as RAS. Alternatively spliced transcript variants encoding different isoforms have been found. [provided by RefSeq, Jun 2010]

Uniprot Description

Adapter protein which associates with tyrosine-phosphorylated growth factor receptors, such as KDR and PDGFRB, or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in the DNA damage response, not in the detection of the damage by ATM/ATR, but for efficient activation of downstream effectors, such as that of CHEK2. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling. Modulates the activation of EIF2AK2/PKR by dsRNA. May play a role in cell adhesion and migration through interaction with ephrin receptors.