Western Blot (WB)
(SGEF Antibody (Center) western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the SGEF antibody detected the SGEF protein (arrow).)
Rabbit anti-Human SGEF Polyclonal Antibody | anti-ARHGEF26 antibody
SGEF Antibody (Center)
Western Blot (WB)
(SGEF Antibody (Center) western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the SGEF antibody detected the SGEF protein (arrow).)
Western Blot (WB)
(SGEF Antibody (Center) western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the SGEF antibody detected the SGEF protein (arrow).)
Immunohistochemistry (IHC)
(SGEF Antibody (Center) immunohistochemistry analysis in formalin fixed and paraffin embedded human liver tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of SGEF Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.)
Immunohistochemistry (IHC)
(SGEF Antibody (Center) immunohistochemistry analysis in formalin fixed and paraffin embedded human liver tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of SGEF Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.)
Ellerbroek, S.M., et al. Mol. Biol. Cell 15(7):3309-3319(2004)
Qi, H., et al. Endocrinology 144(5):1742-1752(2003)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the Rho-guanine nucleotide exchange factor (Rho-GEF) family. These proteins regulate Rho GTPases by catalyzing the exchange of GDP for GTP. The encoded protein specifically activates RhoG and plays a role in the promotion of macropinocytosis. Underexpression of the encoded protein may be a predictive marker of chemoresistant disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011]
Uniprot Description
SGEF: Activates RhoG GTPase by promoting the exchange of GDP by GTP. Required for the formation of membrane ruffles during macropinocytosis. Required for the formation of cup-like structures during trans-endothelial migration of leukocytes. In case of Salmonella enterica infection, activated by SopB, which induces cytoskeleton rearrangements and promotes bacterial entry. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: GEFs; GEFs, Rac/Rho
Chromosomal Location of Human Ortholog: 3q25.2
Cellular Component: ruffle
Molecular Function: Rho guanyl-nucleotide exchange factor activity
Biological Process: endothelial cell morphogenesis
Research Articles on ARHGEF26
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Product Notes
The ARHGEF26 arhgef26 (Catalog #AAA9203156) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 378-406. The SGEF Antibody (Center) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's SGEF can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC). WB~~1:1000. Researchers should empirically determine the suitability of the ARHGEF26 arhgef26 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SGEF, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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