Rabbit anti-Mouse Ikbke Polyclonal Antibody | anti-Ikbke antibody

Mouse Ikbke Antibody (Center)

Cat. Num. AAA9202713

• Gene Names: Ikbke; Ikki; IKK-i; AW558201; IKKepsilon
• Reactivity: Mouse
• Applications: Western Blot, ELISA
• Purity: Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
• Synonyms: Ikbke; Polyclonal Antibody; Mouse Ikbke Antibody (Center); Inhibitor of nuclear factor kappa-B kinase subunit epsilon; I-kappa-B kinase epsilon; IKK-E; IKK-epsilon; IkBKE; Inducible I kappa-B kinase; IKK-i; Ikke; Ikki; anti-Ikbke antibody

• Host: Rabbit
• Reactivity: Mouse
• Clonality: Polyclonal
• Isotype: Rabbit Ig
• Specificity: This Mouse Ikbke antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 470-498 amino acids from the Central region of mouse Ikbke.
• Purity/Purification: Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
• Form/Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
• Concentration: Vial Concentration: 0.45 (varies by lot)
• Sequence Positions: 470-498
• Sequence Length: 717

• Applicable Applications for anti-Ikbke antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB~~1:1000
• Antigen Type: Synthetic Peptide
• Antigen Source: MOUSE
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Western Blot (WB)

(Mouse Ikbke Antibody (Center) western blot analysis in mouse liver tissue lysates (35ug/lane).This demonstrates the Ikbke antibody detected the Ikbke protein (arrow).)

Related Product Information for anti-Ikbke antibody

Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. May play a special role in the immune response. Protects cells against DNA damage-induced cell death (By similarity).

Product Categories/Family for anti-Ikbke antibody

Cancer; Immunology; Signal Transduction

NCBI and Uniprot Product Information

• NCBI GI #: 31981053
• NCBI GeneID: 56489
• NCBI Accession #: NP_062751.2
• NCBI GenBank Nucleotide #: NM_019777.3
• UniProt Accession #: Q9R0T8; Q8C2I3
• Molecular Weight: 80953
• NCBI Official Full Name: inhibitor of nuclear factor kappa-B kinase subunit epsilon
• NCBI Official Synonym Full Names: inhibitor of kappaB kinase epsilon
• NCBI Official Symbol: Ikbke
• NCBI Official Synonym Symbols: Ikki; IKK-i; AW558201; IKKepsilon
• NCBI Protein Information: inhibitor of nuclear factor kappa-B kinase subunit epsilon
• UniProt Protein Name: Inhibitor of nuclear factor kappa-B kinase subunit epsilon
• Protein Family: Inhibitor of nuclear factor kappa-B kinase
• UniProt Gene Name: Ikbke
• UniProt Synonym Gene Names: Ikke; Ikki; I-kappa-B kinase epsilon; IKK-E; IKK-epsilon; IkBKE; IKK-i
• UniProt Entry Name: IKKE_MOUSE

Uniprot Description

IKKE: a oncogenic kinase of the IKK family. Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Plays a pivotal role in coordinating the activation of IRF3 and NF-kappaB in the innate immune response. Its redistribution to PML nuclear bodies upon DNA damage is TOPORS-dependent. Is a breast cancer oncogene that exerts its oncogenic properties through cRel.

Protein type: Protein kinase, Other; EC 2.7.11.10; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; Inhibitor; Other group; IKK family

Cellular Component: nucleoplasm; PML body; cytoplasm; mitochondrial membrane; nucleus

Molecular Function: NF-kappaB-inducing kinase activity; transferase activity; protein serine/threonine kinase activity; protein binding; IkappaB kinase activity; transferase activity, transferring phosphorus-containing groups; nucleotide binding; kinase activity; ATP binding; protein kinase activity

Biological Process: DNA damage response, signal transduction resulting in induction of apoptosis; I-kappaB phosphorylation; response to DNA damage stimulus; protein amino acid phosphorylation; phosphorylation