Rabbit anti-Human TAF4B Polyclonal Antibody | anti-TAF4B antibody

TAF4B (C-Term) Rabbit pAb

Cat. Num. AAA8556714

• Gene Names: TAF4B; SPGF13; TAF2C2; TAFII105
• Reactivity: Human
• Applications: Western Blot, Flow Cytometry, Functional Assay
• Purity: Affinity Purified
• Synonyms: TAF4B; Polyclonal Antibody; TAF4B (C-Term) Rabbit pAb; Transcription initiation factor TFIID subunit 4B; Transcription initiation factor TFIID 105 kDa subunit; TAF(II)105; TAFII-105; TAFII105; TAF2C2; anti-TAF4B antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: Ig
• Purity/Purification: Affinity Purified
• Form/Format: Supplied in PBS with 0.09% (W/V) Sodium Azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
• Sequence Length: 867

• Applicable Applications for anti-TAF4B antibody: Western Blot (WB), Flow Cytometry (FC/FACS)
• Application Notes: WB: 1:1000; FC/FACS: 1:10-50
• Immunogen: This TAF4B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 647-675 amino acids from the C-terminal region of human TAF4B.
• Cellular Localization: Cytoplasm, Nucleus

NCBI and Uniprot Product Information

• NCBI GI #: 656985069
• NCBI GeneID: 6875
• NCBI Accession #: NP_001280654.1
• NCBI GenBank Nucleotide #: NP_001280654.1
• UniProt Accession #: Q92750
• NCBI Official Full Name: transcription initiation factor TFIID subunit 4B isoform 1
• NCBI Official Synonym Full Names: TATA-box binding protein associated factor 4b
• NCBI Official Symbol: TAF4B
• NCBI Official Synonym Symbols: SPGF13; TAF2C2; TAFII105
• NCBI Protein Information: transcription initiation factor TFIID subunit 4B
• UniProt Protein Name: Transcription initiation factor TFIID subunit 4B
• Protein Family: Transcription initiation factor
• UniProt Gene Name: TAF4B
• UniProt Synonym Gene Names: TAF2C2; TAFII105; TAF(II)105; TAFII-105; TAFII105
• UniProt Entry Name: TAF4B_HUMAN

NCBI Description

TATA binding protein (TBP) and TBP-associated factors (TAFs) participate in the formation of the TFIID protein complex, which is involved in initiation of transcription of genes by RNA polymerase II. This gene encodes a cell type-specific TAF that may be responsible for mediating transcription by a subset of activators in B cells. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2014]

Uniprot Description

TAF4B: Cell type-specific subunit of TFIID that may function as a gene-selective coactivator in certain cells. TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. TAFII105 is a transcriptional coactivator of the p65/RELA NF-kappa-B subunit. Involved in the activation of a subset of antiapoptotic genes including TNFAIP3. May be involved in regulating folliculogenesis. Through interaction with OCBA/POU2AF1, acts as a coactivator of B-cell-specific transcription. Belongs to the TAF4 family. 2 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 18q11.2

Cellular Component: nucleoplasm; transcription factor TFIID complex; cytoplasm; nucleolus

Molecular Function: NF-kappaB binding; DNA binding; protein heterodimerization activity; transcription factor activity

Biological Process: transcription from RNA polymerase II promoter; oogenesis; transcription initiation from RNA polymerase II promoter; regulation of transcription, DNA-dependent; viral reproduction; RNA elongation from RNA polymerase II promoter; spermatogenesis; gene expression

Disease: Spermatogenic Failure 13