Human RSV, IgG1 Monoclonal Antibody | anti-RSV antibody

Anti-RSV (Felvizumab), Human IgG1 Antibody

Cat. Num. AAA847318

• Reactivity: Respiratory Syncytial Virus
• Purity: Affinity purified using Protein A
• Synonyms: RSV; IgG1; Monoclonal Antibody; Anti-RSV (Felvizumab); Human IgG1 Antibody; Human Respiratory Syncytical Virus; HRSV; Human respiratory syncytial virus Fusion Protein; HRSV F; anti-RSV antibody

• Host: Human
• Reactivity: Respiratory Syncytial Virus
• Clonality: Monoclonal
• Isotype: Human IgG1, kappa
• Clone Number: RSHZ19
• Specificity: Monoclonal antibody to detect RSV. This antibody is specific for the conserved fusion (F) protein of RSV.
• Purity/Purification: Affinity purified using Protein A
• Form/Format: Colorless liquid. In PBS only

• Antibody Type: Recombinant Antibody
• Immunogen: This antibody was prepared by the humanization of an F protein-specific murine MAb, RSV19. More specifically, molecular techniques were used to insert the complementarity determining regions from murine RSV19 into a human IgG1 heavy and k light chain-variable domain framework.
• Preparation and Storage: Store at -20 degree C; The antibody solution should be gently mixed before use.; Shelf life: ~12 months

Testing Data

Related Product Information for anti-RSV antibody

Recombinant monoclonal antibody to RSV. Manufactured using Recombinant Platform with variable regions (i.e. specificity) from the hybridoma RSHZ19 (Felvizumab). This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques.

Product Categories/Family for anti-RSV antibody

Immunology; Antibodies & Supporting Tools; Research Grade Biosimilar Antibodies

NCBI and Uniprot Product Information

• NCBI GI #: 9629206
• NCBI GeneID: 1489825
• NCBI Accession #: NP_056863.1
• NCBI GenBank Nucleotide #: NC_001781.1
• UniProt Accession #: O36634
• Molecular Weight: 50.1 kDa
• NCBI Official Full Name: fusion protein
• NCBI Official Symbol: F
• NCBI Protein Information: F
• UniProt Protein Name: Fusion glycoprotein F0
• UniProt Gene Name: F
• UniProt Synonym Gene Names: Protein F
• UniProt Entry Name: FUS_HRSVB

Uniprot Description

During virus entry, induces fusion of viral and cellular membranes leading to delivery of the nucleocapsid into the cytoplasm. The fusogenic activity is inactive untill entry into host cell endosome, where a furin-like protease cleaves off a small peptide between F1 and F2. Interacts directly with heparan sulfate and may participates in virus attachment. Furthermore, the F2 subunit was identifed as the major determinant of RSV host cell specificity. Later in infection, proteins F expressed at the plasma membrane of infected cells can mediate fusion with adjacent cells to form syncytia, a cytopathic effect that could lead to tissue necrosis. The fusion protein is also able to trigger p53-dependent apoptosis.