Testing Data
Rabbit anti-Human BICC1 Polyclonal Antibody | anti-BICC1 antibody
BICC1 Antibody (NT)
Appearance: Colorless liquid
Shelf Life: 12 months
Testing Data
Testing Data
Background: BICC1, also known as protein bicaudal C homolog 1, is a 974 amino acid protein that belongs to the BICC family. BICC1 is considered a putative RNA-binding protein and may be involved in regulating gene expression during embryonic development by modulating protein translation. Existing as two alternatively spliced isoforms, BICC1 contains two KH domains as well as one SAM (sterile alpha motif) domain. Both BICC1 isoforms are widely expressed in normal tissues and are found in all brain regions including cerebral cortex, hippocampus and midbrain, although BICC1 isoform 1 is more highly expressed than isoform 2, particularly in nerve tissue. BICC1 can uncouple dishevelled-2 (Dvl-2) signaling from the canonical Wnt pathway in a SAM domain dependent manner, suggesting that the different BICC1 isoforms may play varying biological roles. Genetic variants in BICC1 may be involved in recurrent unipolar major depression. Acts as a negative regulator of Wnt signaling. May be involved in regulating gene expression during embryonic development.
NCBI and Uniprot Product Information
NCBI Description
This gene encodes an RNA-binding protein that is active in regulating gene expression by modulating protein translation during embryonic development. Mouse studies identified the corresponding protein to be under strict control during cell differentiation and to be a maternally provided gene product. [provided by RefSeq, Apr 2009]
Uniprot Description
BICC1: Putative RNA-binding protein. Acts as a negative regulator of Wnt signaling. May be involved in regulating gene expression during embryonic development. Defects in BICC1 are a cause of susceptibility to renal dysplasia, cystic (CYSRD). An anomaly of the kidney characterized by numerous renal cysts and apparent disorder of differentiation of the renal parenchyma. Kidney of affected individuals lack the normal renal bean shape, and the collection drainage system. The cystic, dysplastic kidney contains undifferentiated mesenchyme, cartilaginous tissue, and immature collecting ducts. Belongs to the BicC family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: RNA-binding
Chromosomal Location of Human Ortholog: 10q21.1
Cellular Component: cytoplasm
Biological Process: multicellular organismal development
Disease: Renal Dysplasia, Cystic, Susceptibility To
Research Articles on BICC1
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Product Notes
The BICC1 bicc1 (Catalog #AAA841396) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The BICC1 Antibody (NT) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's BICC1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC). Western blot: ~1:1000, IHC: ~1:10-1:50. Researchers should empirically determine the suitability of the BICC1 bicc1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "BICC1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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