Structure
Rabbit Calsenilin Polyclonal Antibody | anti-KCNIP3 antibody
Calsenilin Antibody
Appearance: Colorless liquid
Shelf Life: 12 months
Structure
Structure
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins, which belong to the recoverin branch of the EF-hand superfamily. Members of this family are small calcium binding proteins containing EF-hand-like domains. They are integral subunit components of native Kv4 channel complexes that may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. The encoded protein also functions as a calcium-regulated transcriptional repressor, and interacts with presenilins. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Uniprot Description
calsenilin: a small calcium-binding protein. Member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belong to the recoverin branch of the EF-hand superfamily. Modulates K4 voltage-gated potassium channels. May regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. Also functions as a calcium-regulated transcriptional repressor, and to interact with presenilins. May play a role in the regulation of PSEN2 proteolytic processing.
Protein type: Calcium-binding; Transcription factor
Chromosomal Location of Human Ortholog: 2q21.1
Cellular Component: Golgi apparatus; voltage-gated potassium channel complex; endoplasmic reticulum; dendrite; nerve terminal; nucleus; cytosol
Molecular Function: protein C-terminus binding; potassium channel regulator activity; DNA binding; potassium channel activity; sequence-specific DNA binding; voltage-gated ion channel activity; calcium ion binding; calcium-dependent protein binding; transcription corepressor activity
Biological Process: regulation of transcription from RNA polymerase II promoter; intracellular protein transport; behavioral response to pain; transcription, DNA-dependent; apoptosis; regulation of neuron apoptosis; negative regulation of transcription from RNA polymerase II promoter; sensory perception of pain; signal transduction
Research Articles on KCNIP3
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Product Notes
The KCNIP3 kcnip3 (Catalog #AAA840768) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Calsenilin Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's Calsenilin can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Western blotting (2-6 ug/ml). However, the optimal conditions should be determined individually. The antibody detects ~30 kDa Calsenilin in samples from human, mouse, and rat origins. Jurkat cell lysate can be used as a positive control. Researchers should empirically determine the suitability of the KCNIP3 kcnip3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Calsenilin, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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