Western Blot (WB)
(Western blot analysis of 5-HT2A expression in HEK293T (A), mouse brain (B), H9C2 (C) whole cell lysates.)
Rabbit 5-HT2A Polyclonal Antibody | anti-HTR2A antibody
Anti-5-HT2A Antibody
Western Blot (WB)
(Western blot analysis of 5-HT2A expression in HEK293T (A), mouse brain (B), H9C2 (C) whole cell lysates.)
Western Blot (WB)
(Western blot analysis of 5-HT2A expression in HEK293T (A), mouse brain (B), H9C2 (C) whole cell lysates.)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes one of the receptors for serotonin, a neurotransmitter with many roles. Mutations in this gene are associated with susceptibility to schizophrenia and obsessive-compulsive disorder, and are also associated with response to the antidepressant citalopram in patients with major depressive disorder (MDD). MDD patients who also have a mutation in intron 2 of this gene show a significantly reduced response to citalopram as this antidepressant downregulates expression of this gene. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
Uniprot Description
5-HT(2A): This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. This receptor is involved in tracheal smooth muscle contraction, bronchoconstriction, and control of aldosterone production. Belongs to the G-protein coupled receptor 1 family.
Protein type: GPCR, family 1; Membrane protein, integral; Receptor, GPCR; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 13q14-q21
Cellular Component: cell soma; integral to plasma membrane; axon; cytoplasmic membrane-bound vesicle; plasma membrane; dendritic shaft; caveola; cytosol
Molecular Function: serotonin binding; serotonin receptor activity; protein complex binding; G-protein alpha-subunit binding; drug binding
Biological Process: cell death; urinary bladder smooth muscle contraction; phosphoinositide 3-kinase cascade; negative regulation of potassium ion transport; thermoregulation; regulation of dopamine secretion; synaptic transmission; positive regulation of MAP kinase activity; behavioral response to cocaine; positive regulation of cell proliferation; detection of temperature stimulus involved in sensory perception of pain; artery smooth muscle contraction; serotonin receptor signaling pathway; aging; regulation of behavior; response to drug; serotonin receptor, phospholipase C activating pathway; regulation of hormone secretion; negative regulation of synaptic transmission, glutamatergic; positive regulation of phosphatidylinositol biosynthetic process; sleep; memory; cellular calcium ion homeostasis; detection of mechanical stimulus involved in sensory perception of pain; positive regulation of peptidyl-tyrosine phosphorylation; phospholipase C activation; release of sequestered calcium ion into cytosol; positive regulation of glycolysis; positive regulation of vasoconstriction; positive regulation of fat cell differentiation
Disease: Schizophrenia; Alcohol Dependence; Anorexia Nervosa, Susceptibility To, 1; Obsessive-compulsive Disorder; Major Depressive Disorder
Research Articles on HTR2A
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Product Notes
The HTR2A htr2a (Catalog #AAA820902) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-5-HT2A Antibody reacts with Human, Mouse, Rat, Bovine, Monkey, Pig and may cross-react with other species as described in the data sheet. AAA Biotech's 5-HT2A can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). WB (1/500 - 1/1000). Researchers should empirically determine the suitability of the HTR2A htr2a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "5-HT2A, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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