Rabbit anti-Rat CD155/PVR Monoclonal Antibody | anti-PVR antibody

Recombinant Anti-CD155/PVR Antibody, Rabbit Monoclonal

Cat. Num. AAA8112583

• Reactivity: Rat
• Applications: ELISA
• Purity: Protein A
• Synonyms: CD155/PVR; Monoclonal Antibody; Recombinant Anti-CD155/PVR Antibody; Rabbit Monoclonal; CD155/PVR Antibody; Rabbit MAb; poliovirus receptor; anti-PVR antibody

• Host: Rabbit
• Reactivity: Rat
• Clonality: Monoclonal
• Isotype: Rabbit IgG
• Clone Number: 026
• Specificity: Rat CD155/PVR.; No cross-reactivity in ELISA with Human PVRL1
• Purity/Purification: Protein A
• Form/Format: Liquid; 0.2um filtered solution in PBS

• Applicable Applications for anti-PVR antibody: ELISA (EIA)
• Application Notes: ELISA: 1:5000-1:10,000
• Antibody Type: Recombinant Antibody
• Immunogen: Recombinant Rat CD155/PVR protein
• Conjugation: Unconjugated
• Preparation: This antibody was obtained from a rabbit immunized with purified, recombinant Rat CD155/PVR (rR CD155/PVR).
• Preparation and Storage: This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Avoid repeated freeze-thaw cycles.

Related Product Information for anti-PVR antibody

CD155, commonly known as PVR (poliovirus receptor) and Necl-5 (nectin-like molecule-5), is a type I transmembrane single-span glycoprotein, and belongs to the nectins and nectin-like (Necl) subfamily. CD155 was originally identified based on its ability to mediate the cell attachment and entry of poliovirus (PV), an etiologic agent of the central nervous system disease poliomyelitis. The normal cellular function is in the establishment of intercellular adherens junctions between epithelial cells. CD155 may assist in an efficient humoral immune response generated within the intestinal immune system. It has been demonstrated that CD155 can be recognized and bond by DNAM-1 and CD96 which promote the adhesion, migration and NK-cell killing, and thus efficiently prime cell-mediated tumor-specific immunity.

Product Categories/Family for anti-PVR antibody

Cancer Drug Targets

References

Freistadt MS, et al. (2000) Hematopoietic cells from CD155-transgenic mice express CD155 and support poliovirus replication ex vivo. Microb Pathog. 29(4): 203-12.Sato T, et al. (2004) Involvement of heterophilic trans-interaction of Necl-5/Tage4/PVR/CD155 with nectin-3 in formation of nectin-and cadherin-based adherens junctions. Genes Cells. 9(9): 791-9.Kakunaga S, et al. (2004) Enhancement of serum-and platelet-derived growth factor-induced cell proliferation by Necl-5/Tage4/poliovirus receptor/CD155 through the Ras-Raf-MEK-ERK signaling. J Biol Chem. 279(35): 36419-25.Sato T, et al. (2005) Common signaling pathway is used by the trans-interaction of Necl-5/Tage4/PVR/CD155 and nectin, and of nectin and nectin during the formation of cell-cell adhesion. Cancer Sci. 96(9): 578-89.Minami Y, et al. (2007) Involvement of up-regulated Necl-5/Tage4/PVR/CD155 in the loss of contact inhibition in transformed NIH3T3 cells. Biochem Biophys Res Commun. 352(4): 856-60.

NCBI and Uniprot Product Information

• NCBI GI #: 148539963
• NCBI GeneID: 25066
• NCBI Accession #: NP_058772.2
• NCBI GenBank Nucleotide #: NM_017076.2
• UniProt Accession #: Q5U334
• Molecular Weight: 44,512 Da
• NCBI Official Full Name: poliovirus receptor
• UniProt Protein Name: Poliovirus receptor
• Protein Family: Poliovirus receptor
• UniProt Gene Name: PVR
• UniProt Entry Name: Q5U334_RAT

NCBI Description

may act as a receptor to mediate entry of some viruses [RGD, Feb 2006]

Uniprot Description

PVR: Mediates NK cell adhesion and triggers NK cell effector functions. Binds two different NK cell receptors: CD96 and CD226. These interactions accumulates at the cell-cell contact site, leading to the formation of a mature immunological synapse between NK cell and target cell. This may trigger adhesion and secretion of lytic granules and IFN-gamma and activate cytoxicity of activated NK cells. May also promote NK cell-target cell modular exchange, and PVR transfer to the NK cell. This transfer is more important in some tumor cells expressing a lot of PVR, and may trigger fratricide NK cell activation, providing tumors with a mechanism of immunoevasion. Plays a role in mediating tumor cell invasion and migration. Serves as a receptor for poliovirus attachment to target cells. May play a role in axonal transport of poliovirus, by targeting virion-PVR-containing endocytic vesicles to the microtubular network through interaction with DYNLT1. This interaction would drive the virus-containing vesicle to the axonal retrograde transport. Belongs to the nectin family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Immunoglobulin superfamily; Membrane protein, integral; Receptor, misc.; Motility/polarity/chemotaxis

Cellular Component: focal adhesion; cell surface; plasma membrane; integral to membrane

Molecular Function: viral receptor activity; cell adhesion molecule binding

Biological Process: entry of virus into host cell; cell-cell adhesion; cell migration; positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target; susceptibility to natural killer cell mediated cytotoxicity; positive regulation of natural killer cell mediated cytotoxicity