Testing Data
(Analysis of PVR(CD155) expression on Raw264.7 cells. The cells were treated with Mouse BD Fc Block' purified anti-CD16/CD32 mAb 2.4G2 and stained with PE-conjugated anti-Mouse PVR(CD155, 50259-R305-P). The histogram were derived from the gated events based on light scattering characteristics of viable cells.)
Rabbit anti-Mouse CD155/PVR Monoclonal Antibody | anti-PVR antibody
Recombinant Anti-CD155/PVR Antibody (PE), Rabbit Monoclonal
Reactivity
Mouse
Applications
Flow Cytometry, Functional Assay
Purity
Protein A
Synonyms
CD155/PVR; Monoclonal Antibody; Recombinant Anti-CD155/PVR Antibody (PE); Rabbit Monoclonal; CD155/PVR Antibody (PE); Rabbit MAb; poliovirus receptor; Anti-3830421F03Rik Antibody; Anti-CD155 Antibody; Anti-D7Ertd458e Antibody; Anti-HVED Antibody; Anti-mE4 Antibody; Anti-necl-5 Antibody; Anti-PVS Antibody; Anti-Taa1 Antibody; Anti-Tage4 Antibody; anti-PVR antibody
Host
Rabbit
Reactivity
Mouse
Clonality
Monoclonal
Isotype
Rabbit IgG
Clone Number
305
Specificity
Mouse CD155/PVR
Purity/Purification
Protein A
Form/Format
Liquid; Aqueous solution containing 0.5% BSA and 0.1% sodium azide
Concentration
10ul/Test, 0.1mg/ml (varies by lot)
Applicable Applications for anti-PVR antibody
Flow Cytometry (FC/FACS/FCM)
Antibody Type
Recombinant Antibody
Immunogen
Recombinant Mouse CD155 protein
Conjugation
PE
Preparation
This antibody was obtained from a rabbit immunized with purified, recombinant Mouse CD155/PVR (rM CD155/PVR) and conjugated with PE under optimum conditions, the unreacted PE was removed.
Preparation and Storage
This antibody can be stored at 2-8 degree C for twelve months without detectable loss of activity. Protected from prolonged exposure to light. Do not freeze! Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.
Testing Data
(Analysis of PVR(CD155) expression on Raw264.7 cells. The cells were treated with Mouse BD Fc Block' purified anti-CD16/CD32 mAb 2.4G2 and stained with PE-conjugated anti-Mouse PVR(CD155, 50259-R305-P). The histogram were derived from the gated events based on light scattering characteristics of viable cells.)
Testing Data
(Analysis of PVR(CD155) expression on Raw264.7 cells. The cells were treated with Mouse BD Fc Block' purified anti-CD16/CD32 mAb 2.4G2 and stained with PE-conjugated anti-Mouse PVR(CD155, 50259-R305-P). The histogram were derived from the gated events based on light scattering characteristics of viable cells.)
Related Product Information for anti-PVR antibody
CD155, commonly known as PVR (poliovirus receptor) and Necl-5 (nectin-like molecule-5), is a type I transmembrane single-span glycoprotein, and belongs to the nectins and nectin-like (Necl) subfamily. CD155 was originally identified based on its ability to mediate the cell attachment and entry of poliovirus (PV), an etiologic agent of the central nervous system disease poliomyelitis. The normal cellular function is in the establishment of intercellular adherens junctions between epithelial cells. CD155 may assist in an efficient humoral immune response generated within the intestinal immune system. It has been demonstrated that CD155 can be recognized and bond by DNAM-1 and CD96 which promote the adhesion, migration and NK-cell killing, and thus efficiently prime cell-mediated tumor-specific immunity.
Product Categories/Family for anti-PVR antibody
References
Freistadt MS, et al. (2000) Hematopoietic cells from CD155-transgenic mice express CD155 and support poliovirus replication ex vivo. Microb Pathog. 29(4): 203-12.Sato T, et al. (2004) Involvement of heterophilic trans-interaction of Necl-5/Tage4/PVR/CD155 with nectin-3 in formation of nectin-and cadherin-based adherens junctions. Genes Cells. 9(9): 791-9.Kakunaga S, et al. (2004) Enhancement of serum-and platelet-derived growth factor-induced cell proliferation by Necl-5/Tage4/poliovirus receptor/CD155 through the Ras-Raf-MEK-ERK signaling. J Biol Chem. 279(35): 36419-25.Sato T, et al. (2005) Common signaling pathway is used by the trans-interaction of Necl-5/Tage4/PVR/CD155 and nectin, and of nectin and nectin during the formation of cell-cell adhesion. Cancer Sci. 96(9): 578-89.Minami Y, et al. (2007) Involvement of up-regulated Necl-5/Tage4/PVR/CD155 in the loss of contact inhibition in transformed NIH3T3 cells. Biochem Biophys Res Commun. 352(4): 856-60.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
44,668 Da
NCBI Official Full Name
poliovirus receptor
UniProt Protein Name
Poliovirus receptor
Protein Family
UniProt Gene Name
Pvr
UniProt Synonym Gene Names
D7Ertd458e
UniProt Entry Name
Q8K094_MOUSE
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Product Notes
The PVR pvr (Catalog #AAA8111282) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Recombinant Anti-CD155/PVR Antibody (PE), Rabbit Monoclonal reacts with Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's CD155/PVR can be used in a range of immunoassay formats including, but not limited to, Flow Cytometry (FC/FACS/FCM). Researchers should empirically determine the suitability of the PVR pvr for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CD155/PVR, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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