Immunohistochemistry (IHC)
(Immunochemical staining of human C6orf130 in human brain with rabbit polyclonal antibody at 1:100 dilution, formalin-fixed paraffin embedded sections.)
Rabbit anti-Human C6orf130 Polyclonal Antibody | anti-OARD1 antibody
Anti-C6orf130 Antibody, Rabbit Polyclonal
Reactivity
Human
Applications
Immunohistochemistry
Purity
Protein A & Antigen Affinity
Synonyms
C6orf130; Polyclonal Antibody; Anti-C6orf130 Antibody; Rabbit Polyclonal; C6orf130/OARD1 Antibody; Rabbit PAb; Antigen Affinity Purified; O-acyl-ADP-ribose deacylase 1; Anti-dJ34B21.3 Antibody; Anti-TARG1 Antibody; anti-OARD1 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
Rabbit IgG
Specificity
Human C6orf130/OARD1
Purity/Purification
Protein A & Antigen Affinity
Form/Format
Liquid; PBS, pH7.0 with 0.03% Proclin300
Applicable Applications for anti-OARD1 antibody
Immunohistochemistry-Paraffin (IHC-P)
Application Notes
IHC-P: 1:50-1:200
Immunogen
E Coli-derived Human C6orf130/OARD1 fragment
Conjugation
Unconjugated
Preparation
Produced in rabbits immunized with E Coli-derived Human C6orf130/OARD1 fragment, and purified by antigen affinity chromatography.
Preparation and Storage
This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Avoid repeated freeze-thaw cycles.
Immunohistochemistry (IHC)
(Immunochemical staining of human C6orf130 in human brain with rabbit polyclonal antibody at 1:100 dilution, formalin-fixed paraffin embedded sections.)
Immunohistochemistry (IHC)
(Immunochemical staining of human C6orf130 in human brain with rabbit polyclonal antibody at 1:100 dilution, formalin-fixed paraffin embedded sections.)
Related Product Information for anti-OARD1 antibody
OARD1 (O-Acyl-ADP-Ribose Deacylase 1, also known as TARG1, C6orf130) is a Protein Coding gene. The OARD1 gene, located on 6p21.1, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, chicken, zebrafish, fruit fly, and mosquito. The protein encoded by this gene is a deacylase that can convert O-acetyl-ADP-ribose to ADP-ribose and acetate, O-propionyl-ADP-ribose to ADP-ribose and propionate, and O-butyryl-ADP-ribose to ADP-ribose and butyrate. The ADP-ribose product can inhibit these reactions through a competitive feedback loop. TARG1/C6orf130 is a macrodomain protein that hydrolyzes mono-ADP-ribosylation and interacts with poly-ADP-ribose chains. Diseases associated with OARD1 include Arthrogryposis, Renal Dysfunction, And Cholestasis 1 and Hypercholesterolemia, Familial, 4. 235 organisms have orthologs with human gene OARD1.
References
Rosenthal F, et al. (2013) Macrodomain-containing proteins are new mono-adp-ribosylhydrolases. Nat Struct Mol Biol 20 (4): 502-507.Peterson FC, et al. (2011) Orphan macrodomain protein (human c6orf130) is an o-acyl-adp-ribose deacylase: Solution structure and catalytic properties. J Biol Chem 286 (41): 35955-35965.Butepage M, et al. (2018) Nucleolar-nucleoplasmic shuttling of targ1 and its control by DNA damage-induced poly-adp-ribosylation and by nucleolar transcription. Sci Rep 8 (1): 6748.
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Product Notes
The OARD1 (Catalog #AAA8109922) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-C6orf130 Antibody, Rabbit Polyclonal reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's C6orf130 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry-Paraffin (IHC-P). IHC-P: 1:50-1:200. Researchers should empirically determine the suitability of the OARD1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "C6orf130, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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