Mouse anti-Human IL1R1 Monoclonal Antibody | anti-IL1R1 antibody

Anti-IL1R1 Antibody, Mouse Monoclonal

Cat. Num. AAA8101137

• Gene Names: IL1R1; P80; IL1R; IL1RA; CD121A; D2S1473; IL-1R-alpha
• Reactivity: Human
• Applications: ELISA
• Purity: Protein A
• Synonyms: IL1R1; Monoclonal Antibody; Anti-IL1R1 Antibody; Mouse Monoclonal; IL1R1/IL-1R1/IL-1 RI Antibody; Mouse MAb; interleukin 1 receptor; type I; Anti-CD121A Antibody; Anti-D2S1473 Antibody; Anti-IL-1 RI Antibody; Anti-IL-1R-alpha Antibody; Anti-IL-1R1 Antibody; Anti-IL1R Antibody; Anti-IL1RA Antibody; Anti-P80 Antibody; anti-IL1R1 antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Clone Number: 08
• Specificity: Human IL1R1/IL-1R1/IL-1 RI
• Purity/Purification: Protein A
• Form/Format: Liquid; 0.2um filtered solution in PBS

• Applicable Applications for anti-IL1R1 antibody: ELISA (EIA) (Cap)
• Application Notes: ELISA (Cap): This antibody will detect Human IL1R1/IL-1R1/IL-1 RI in ELISA pair set.; In a sandwich ELISA, it can be used as capture antibody.
• Immunogen: Recombinant Human IL1R1/IL-1R1/IL-1 RI Protein
• Conjugation: Unconjugated
• Preparation: This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human IL1R1/IL-1R1/IL-1 RI (rh IL1R1/IL-1R1/IL-1 RI). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
• Preparation and Storage: This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Avoid repeated freeze-thaw cycles.

Related Product Information for anti-IL1R1 antibody

Interleukin 1 receptor, type I (IL-1R1) also known as CD121a (Cluster of Differentiation 121a), is an interleukin receptor. IL-1R1/CD121a is a cytokine receptor that belongs to the interleukin 1 receptor family. This protein is a receptor for interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I (IL1R1/IL1RA). IL-1R1/CD121a is an important mediator involved in many cytokines induced immune and inflammatory responses. This protein has been characterized by pharmacological and molecular techniques in the mouse brain. The spindle-shaped astrocytes enclose the wound, separating the healthy from damaged neural tissue. The shape change and subsequent repair processes are IL-1beta activity-dependent, acting through the IL-1 type 1 receptor (IL-1R1), as co-application of the IL-1type 1 receptor antagonist protein (IL-1ra) blocks IL-1beta induced effects. In the spleen, a slight increase in IL-1R ACP and IL-1R1 was observed during the first hours following LPS stimulation. In conclusion, IL-1R AcP mRNA is expressed in the brain and in other tissues where IL-1R1/CD121a transcripts are found. However, the regulation of its expression is distinct from IL-1R1/CD121a. The high level of expression and the lack of regulation of IL-1R AcP transcripts in the brain under inflammatory conditions suggest that the protein might be constitutively expressed in excess.

Product Categories/Family for anti-IL1R1 antibody

Neuroinflammation; IL1 signaling pathway

References

Dale M, et al. (1999). "Interleukin-1 receptor cluster: gene organization of IL1R2, IL1R1, IL1RL2 (IL-1Rrp2), IL1RL1 (T1/ST2), and IL18R1 (IL-1Rrp) on human chromosome 2q.". Genomics 57 (1): 177-9.Joos L, et al. (2001). "Association of IL-1beta and IL-1 receptor antagonist haplotypes with rate of decline in lung function in smokers.". Thorax 56 (11): 863-6.Vigers GP, et al. (1997). "Crystal structure of the type-I interleukin-1 receptor complexed with interleukin-1beta.". Nature 386 (6621): 190-4.

NCBI and Uniprot Product Information

• NCBI GI #: 4504659
• NCBI GeneID: 3554
• NCBI Accession #: NP_000868.1
• NCBI GenBank Nucleotide #: NM_000877.2
• UniProt Accession #: P14778; Q587I7
• Molecular Weight: 80kDa
• NCBI Official Full Name: interleukin-1 receptor type 1
• NCBI Official Synonym Full Names: interleukin 1 receptor, type I
• NCBI Official Symbol: IL1R1
• NCBI Official Synonym Symbols: P80; IL1R; IL1RA; CD121A; D2S1473; IL-1R-alpha
• NCBI Protein Information: interleukin-1 receptor type 1; IL-1R-1; IL-1RT1; IL-1RT-1; antigen CD121a; interleukin receptor 1; interleukin-1 receptor alpha; interleukin-1 receptor type I; CD121 antigen-like family member A; interleukin 1 receptor alpha, type I
• UniProt Protein Name: Interleukin-1 receptor type 1
• Protein Family: Interleukin-1 receptor
• UniProt Gene Name: IL1R1
• UniProt Synonym Gene Names: IL1R; IL1RA; IL1RT1; IL-1R-1; IL-1RT-1; IL-1RT1; IL-1R-alpha; mIL-1R1; mIL-1RI; sIL-1R1; sIL-1RI
• UniProt Entry Name: IL1R1_HUMAN

Uniprot Description

IL-1RA: Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the corecptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex. Belongs to the interleukin-1 receptor family.

Protein type: EC 2.7.11.25; Membrane protein, integral; Receptor, cytokine

Chromosomal Location of Human Ortholog: 2q12

Cellular Component: cell surface; membrane; integral to plasma membrane; plasma membrane; extracellular region

Molecular Function: interleukin-1, Type I, activating receptor activity; protein binding; signal transducer activity; transmembrane receptor activity; protease binding; platelet-derived growth factor receptor binding; interleukin-1 receptor activity

Biological Process: cell surface receptor linked signal transduction; regulation of inflammatory response; immune response