Structure
Ciliobrevin D, Inhibitor
Ciliobrevin D
Purity
>98% (HPLC)
Synonyms
Ciliobrevin D; inhibitor
Purity/Purification
>98% (HPLC)
Target
Dynein
Receptor
Dynein
Chemical Name
2-(7-chloro-4-oxo-3, 4-dihydroquinazolin-2(1H)-ylidene)-3-(2, 4-dichlorophenyl)-3-oxopropanenitrile
SMILES
N#C/C(C(C1=CC=C(Cl)C=C1Cl)=O)=C(N2)/NC3=C(C=CC(Cl)=C3)C2=O
Molecular Formula
C17H8Cl3N3O2
CAS Number
1370554-01-0
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for Ciliobrevin D, inhibitor
Ciliobrevin D is a cell-permeable, reversible, specific inhibitor of cytoplasmic dynein, blocks dynein-dependent microtubule gliding and ATPase activity while sparing kinesin dependent cellular trafficking; selectively affects retrograde transport, inhibits the bidirectional transport of organelles along sensory axons and impairs NGF-mediated regulation of growth cones and axon branches, disrupts spindle pole focusing and kinetochore-microtubule attachment at 10-40uM.
Product Categories/Family for Ciliobrevin D, inhibitor
References
1. Sainath R, et al. Dev Neurobiol. 2015 Jul; 75 (7):757-77.
2. Melemedjian OK, et al. Mol Pain. 2014 Jul 4; 10:45.
3. See SK, et al. ACS Chem Biol. 2016 Jan 15; 11 (1):53-60.
4. Firestone AJ, et al. Nature. 2012 Mar 18; 484 (7392):125-9.
2. Melemedjian OK, et al. Mol Pain. 2014 Jul 4; 10:45.
3. See SK, et al. ACS Chem Biol. 2016 Jan 15; 11 (1):53-60.
4. Firestone AJ, et al. Nature. 2012 Mar 18; 484 (7392):125-9.
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Product Notes
The Ciliobrevin D (Catalog #AAA3601528) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Ciliobrevin D, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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