Mouse anti-Human I-309 Monoclonal Antibody | anti-CCL1 antibody

Anti-I-309 Antibody, Mouse Monoclonal

Cat. Num. AAA8100506

• Gene Names: CCL1; P500; SISe; TCA3; I-309; SCYA1
• Reactivity: Human
• Applications: ELISA
• Purity: Protein A
• Synonyms: I-309; Monoclonal Antibody; Anti-I-309 Antibody; Mouse Monoclonal; I-309/CCL1 Antibody; Mouse MAb; chemokine (C-C motif) ligand 1; Anti-P500 Antibody; Anti-SCYA1 Antibody; Anti-SISe Antibody; Anti-TCA3 Antibody; anti-CCL1 antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: Mouse IgG2a
• Clone Number: 01
• Specificity: Human I-309/CCL1
• Purity/Purification: Protein A
• Form/Format: Liquid; 0.2um filtered solution in PBS

• Applicable Applications for anti-CCL1 antibody: ELISA (EIA)
• Application Notes: ELISA: 1:1000-1:2000
• Immunogen: Recombinant Human I-309/CCL1 Protein
• Conjugation: Unconjugated
• Preparation: This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human I-309/CCL1 (rh I-309/CCL1). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
• Preparation and Storage: This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Avoid repeated freeze-thaw cycles.

Related Product Information for anti-CCL1 antibody

CCL1 or chemokine (C-C motif) ligand 1, also known as I-309 or TCA-3, is a member of the chemokine (C-C motif) ligand family. The C-C chemokines have two cysteines nearby the amino terminus. There have been at least 27 distinct members of this subgroup reported for mammals, called C-C chemokine ligands (CCL)-1 to 28. I-309/CCL1/TCA-3 interacts with the G protein-linked transmembrane chemokine receptors CCR8 and induces biochemical events that may result in the control of chemotaxis, proliferation, apoptosis and adhesion. It has been demonstrated that I-309/CCL1/TCA-3 displays chemotactic activity for monocytes and other cell types such as NK cells and dendritic cells, but not for neutrophils. Furthermore, as the only known physiological ligand for CCR8, I-309/CCL1/TCA-3 was identified as a potent inhibitor of HIV-1 envelope-mediated cell-cell fusion and virus infection. I-309/CCL1/TCA-3 induces significant levels of LTC4 from elicited eosinophils.

References

Miller MD, et al. (1992) The human cytokine I-309 is a monocyte chemoattractant. Proc Natl Acad Sci. 89 (7): 2950-4.Roos RS, et al. (1997) Identification of CCR8, the receptor for the human CC chemokine I-309. J Biol Chem. 272 (28): 17251-4.Oliveira SH, et al. (2002) Increased responsiveness of murine eosinophils to MIP-1beta (CCL4) and TCA-3 (CCL1) is mediated by their specific receptors, CCR5 and CCR8. J Leukoc Biol. 71(6): 1019-25.

NCBI and Uniprot Product Information

• NCBI GI #: 4506833
• NCBI GeneID: 6346
• NCBI Accession #: NP_002972.1
• NCBI GenBank Nucleotide #: NM_002981.2
• UniProt Accession #: P22362; Q2M309; B2R5G9
• Molecular Weight: 10,992 Da
• NCBI Official Full Name: C-C motif chemokine 1
• NCBI Official Synonym Full Names: chemokine (C-C motif) ligand 1
• NCBI Official Symbol: CCL1
• NCBI Official Synonym Symbols: P500; SISe; TCA3; I-309; SCYA1
• NCBI Protein Information: C-C motif chemokine 1; T lymphocyte-secreted protein I-309; inflammatory cytokine I-309; small inducible cytokine A1 (I-309, homologous to mouse Tca-3)
• UniProt Protein Name: C-C motif chemokine 1
• Protein Family: Cyclin
• UniProt Gene Name: CCL1
• UniProt Synonym Gene Names: SCYA1
• UniProt Entry Name: CCL1_HUMAN

NCBI Description

This antimicrobial gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, is secreted by activated T cells and displays chemotactic activity for monocytes but not for neutrophils. It binds to the chemokine (C-C motif) receptor 8. [provided by RefSeq, Sep 2014]

Uniprot Description

CCL1: Cytokine that is chemotactic for monocytes but not for neutrophils. Binds to CCR8. Belongs to the intercrine beta (chemokine CC) family.

Protein type: Chemokine; Secreted, signal peptide; Motility/polarity/chemotaxis; Secreted

Chromosomal Location of Human Ortholog: 17q12

Cellular Component: extracellular space

Molecular Function: chemokine activity

Biological Process: cellular calcium ion homeostasis; viral reproduction; immune response; signal transduction; chemotaxis