Thiolutin Small Molecule

Thiolutin

Cat. Num. AAA808079

• Purity: >=98% (TLC); NMR (Conforms)
• Synonyms: Thiolutin; RNA polymerase inhibitor; N-(4; 5-Dihydro-4-methyl-5-oxo-1; 2-d¬ithiolo[4; 3-b]pyrrol-6-yl)acetamide; Thiolutin small molecule

• Host: Synthetic
• Purity/Purification: >=98% (TLC); NMR (Conforms)
• Form/Format: Yellow powder

• Solubility: May be dissolved in DMSO (15 mg/ml)
• CAS Number: 87-11-6
• Molecular Formula: C8H8N2O2S2
• SMILES: CC(=O)NC1=C2C(=CSS2)N(C1=O)C
• InChI: 1S/C8H8N2O2S2/c1-4(11)9-6-7-5(3-13-14-7)10(2)8(6)12/h3H,1-2H3,(H,9,11)
• InChI Key: MHMRAFONCSQAIA-UHFFFAOYSA-N
• PubChem CID: 6870
• Preparation and Storage: Store at -20 degree C.

Chemical Structure

(Chemical structure of Thiolutin (SIH-375), a HSP27 perturbing agent. CAS #: 87-11-6. Molecular Formula: C8H8N2O2S2. Molecular Weight: 228.3 g/mol.)

Related Product Information for Thiolutin small molecule

Thiolutin is a sulfur antibiotic. Studies show the potential transcriptional inhibition on yeast degradation. By calculating the mRNA decay rates of transcription at different times after inhibition, it was evident that the effect of Thiolutin on the various degradation pathways of mRNA compromises the stability of the mRNA and the mechanism of gene expression (1). In pharmacology is known to inhibit endothelial cell adhesion by perturbing Hsp 27 interactions with components of the actin and intermediate filament cytoskeleton (2). Studies shown the inhibition of tumor cell-induced angionegesis in vivo, adhesion of endothelial cells to vitronectin (IC50=0.83 uM) (3). Potentially inhibits developmental angiogenesis in zebrafish (2). Cell permeable. Active in vivo.

Product Categories/Family for Thiolutin small molecule

Small Molecules; Inhibitor; Cell Signaling; Epigenetics and Nuclear Signaling

References

1. Pelechano V. and Perez-Ortin J. (2008) Yeast 25: 85-92. 2. Jia Y., et al. (2010) Cell Stress Chaperones 15: 165. 3. Minamiguchi K., et al. (2001) International J. Cancer. 93: 307.