Mouse Chloride anion exchanger (SLC26A3) ELISA Kit | SLC26A3 elisa kit
Mouse Chloride anion exchanger (SLC26A3) ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a transmembrane glycoprotein that transports chloride ions across the cell membrane in exchange for bicarbonate ions. It is localized to the mucosa of the lower intestinal tract, particularly to the apical membrane of columnar epithelium and some goblet cells. The protein is essential for intestinal chloride absorption, and mutations in this gene have been associated with congenital chloride diarrhea. [provided by RefSeq, Oct 2008]
Uniprot Description
SLC26A3: Chloride/bicarbonate exchanger. Mediates the efficient absorbtion of chloride ions in the colon, participating in fluid homeostasis. Defects in SLC26A3 are the cause of diarrhea type 1 (DIAR1); also known as congenital chloride diarrhea (CLD). DIAR1 is a disease characterized by voluminous watery stools containing an excess of chloride. The children with this disease are often premature. Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
Protein type: Membrane protein, multi-pass; Transporter, SLC family; Transporter; Membrane protein, integral
Chromosomal Location of Human Ortholog: 7q31
Cellular Component: membrane; integral to plasma membrane; brush border membrane; apical plasma membrane; plasma membrane
Molecular Function: bicarbonate transmembrane transporter activity; protein binding; transporter activity; chloride transmembrane transporter activity; anion:anion antiporter activity; transcription cofactor activity; secondary active sulfate transmembrane transporter activity; transcription factor activity
Biological Process: intracellular pH elevation; regulation of transcription, DNA-dependent; bicarbonate transport; membrane hyperpolarization; ion transport; excretion; transmembrane transport; anion transport; sperm capacitation
Disease: Diarrhea 1, Secretory Chloride, Congenital
Research Articles on SLC26A3
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Product Notes
The Mouse SLC26A3 slc26a3 (Catalog #AAA7216555) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA7216555 ELISA Kit recognizes Mouse SLC26A3. It is sometimes possible for the material contained within the vial of "Chloride anion exchanger (SLC26A3), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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