Porcine E3 ubiquitin-protein ligase RNF19A (RNF19A) ELISA Kit | RNF19A elisa kit
Porcine E3 ubiquitin-protein ligase RNF19A (RNF19A) ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the ring between ring fingers (RBR) protein family, and the encoded protein contains two RING-finger motifs and an in between RING fingers motif. This protein is an E3 ubiquitin ligase that is localized to Lewy bodies, and ubiquitylates synphilin-1, which is an interacting protein of alpha synuclein in neurons. The encoded protein may be involved in amyotrophic lateral sclerosis and Parkinson's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Uniprot Description
RNF19: E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, such as SNCAIP or CASR. Specifically ubiquitinates pathogenic SOD1 variants, which leads to their proteasomal degradation and to neuronal protection. Belongs to the RBR family. RNF19 subfamily. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Transcription, coactivator/corepressor; Membrane protein, integral; Membrane protein, multi-pass; EC 6.3.2.-; EC 6.3.2.19; Ubiquitin ligase; Ligase; Ubiquitin conjugating system
Chromosomal Location of Human Ortholog: 8q22
Cellular Component: centrosome; cytoplasm; integral to membrane
Molecular Function: zinc ion binding; transcription factor binding; ligase activity
Biological Process: protein ubiquitination; microtubule cytoskeleton organization and biogenesis
Research Articles on RNF19A
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Product Notes
The Porcine RNF19A rnf19a (Catalog #AAA7208833) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA7208833 ELISA Kit recognizes Porcine RNF19A. It is sometimes possible for the material contained within the vial of "E3 ubiquitin-protein ligase RNF19A (RNF19A), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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