Tyrosine-protein phosphatase non-receptor type substrate 1 Recombinant Protein | Sirpa recombinant protein
Tyrosine-protein phosphatase non-receptor type substrate 1
Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.
NCBI and Uniprot Product Information
Uniprot Description
SHPS1: Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function. Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. Binds PTPN11 when tyrosine-phosphorylated, except in macrophages, where it primarily binds PTPN6. Binds GRB2 in vitro. Binds FGR. Binds JAK2 irrespective of its phosphorylation status and forms a stable complex. Binds SCAP1 and/or SCAP2. The resulting complex recruits FYB. Binds PTK2B. Ubiquitous. Highly expressed in brain. Detected on myeloid cells, but not T-cells. Detected at lower levels in heart, placenta, lung, testis, ovary, colon, liver, small intestine, prostate, spleen, kidney, skeletal muscle and pancreas. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Cell adhesion; Cell surface; Motility/polarity/chemotaxis; Receptor, misc.; Membrane protein, integral
Cellular Component: integral to plasma membrane
Molecular Function: protein binding; protein phosphorylated amino acid binding
Biological Process: actin filament organization; cell migration; cell motility; cell-matrix adhesion; cytoskeleton organization and biogenesis; hemopoietic progenitor cell differentiation; phagocytosis, engulfment; phagocytosis, recognition; positive regulation of phagocytosis
Research Articles on Sirpa
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Product Notes
The Sirpa sirpa (Catalog #AAA7043331) is a Recombinant Protein produced from Cell Free Expression and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 32-513aa; full length protein. The amino acid sequence is listed below: KELKVTQPEK SVSVAAGDST VLNCTLTSLL PVGPIKWYRG VGQSRLLIYS FTGEHFPRVT NVSDATKRNN MDFSIRISNV TPEDAGTYYC VKFQKGPSEP DTEIQSGGGT EVYVLAKPSP PEVSGPADRG IPDQKVNFTC KSHGFSPRNI TLKWFKDGQE LHHLETTVNP SGKNVSYNIS STVRVVLNSM DVHSKVICEV AHITLDRSPL RGIANLSNFI RVSPTVKVTQ QSPTSMNQVN LTCRAERFYP EDLQLIWLEN GNVSRNDTPK NLTKNTDGTY NYTSLFLVNS SAHREDVVFT CQVKHDQQPA ITRNHTVLGL AHSSDQGSMQ TFPGNNATHN WNVFIGVGVA CALLVVLLMA ALYLLRIKQK KAKGSTSSTR LHEPEKNARE ITQVQSLIQD TNDINDITYA DLNLPKEKKP APRAPEPNNH TEYASIETGK VPRPEDTLTY ADLDMVHLSR AQPAPKPEPS FSEYASVQVQ RK. It is sometimes possible for the material contained within the vial of "Tyrosine-protein phosphatase non-receptor type substrate 1, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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