Cation channel sperm-associated protein 2 (Catsper2) Recombinant Protein | Catsper2 recombinant protein
Recombinant Rat Cation channel sperm-associated protein 2 (Catsper2)
Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.
NCBI and Uniprot Product Information
Uniprot Description
CATSPER2: Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte. Activated by extracellular progesterone and prostaglandins following the sequence: progesterone > PGF1-alpha = PGE1 > PGA1 > PGE2 >> PGD2. The primary effect of progesterone activation is to shift voltage dependence towards more physiological, negative membrane potentials; it is not mediated by metabotropic receptors and second messengers. Sperm capacitation enhances the effect of progesterone by providing additional negative shift. Also activated by the elevation of intracellular pH. Defects in CATSPER2 are a cause of deafness-infertility syndrome (DIS). DIS is characterized by deafness and infertility and is caused by large contiguous gene deletions at 15q15.3 that removes both STRC and CATSPER2 genes. Belongs to the cation channel sperm-associated (TC 1.A.1.19) family. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Membrane protein, multi-pass
Cellular Component: plasma membrane
Molecular Function: calcium activated cation channel activity; voltage-gated calcium channel activity
Biological Process: calcium ion transport; cell differentiation; fertilization; multicellular organismal development; sperm capacitation; sperm motility; spermatogenesis
Research Articles on Catsper2
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Product Notes
The Catsper2 catsper2 (Catalog #AAA7010770) is a Recombinant Protein produced from Cell Free Expression and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 1-584aa; full length protein. This is a recombinant transmembrane protein expressed in a cell-free expression system. Researchers should empirically determine the suitability of the Catsper2 catsper2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: MAHERGHLQL PRADAIRSKL IDTFSLIEHL QGLSQAVPRH TLREILDPAC QKKLMLGDQE QLVRFSIRAR RMGHITHAQR LLSRLRVRCG GRPPLSLWAG WVLDSSIFSN FIISLIFLNT FVLMVEIELM NSTNTSLWPL KLALEVTDWF ILLSFIVEIL LMWLASFFLF WKNAWSVFDF VVTMLSLLPE FVVLIGVSAD SVWLQLLRVS RVLRSLKLFA RFPQIKVILL ALVRALKSMT FLLMLLLIFF YVFAVAGVYF FKEYSRSTIE NLEYNMFFSD LLNSLVTVFI LFTLDHWYAV LQDVWKVPEA SRVFSSIYVI LWLLLGSIIF RNIIVAMMVT NFQNIRNELH EEMTHLEVQY KADIFKRRII QRRQQSESLR GTSQGKVSED ITETSEATDE EKSEAEESEE EKSEEEKSDV EKSDEEKNDE EKSDEEENDE EKSDVEKSDE EKNDEEKGYT EKVYSGRTFV ERSYAERSFA GKAENEKVQK ELKEKAYPGS PPNSSSHDEA FAADDTYLEN LDWETLVHEN LPGLMDMDQD DRVVWPRDSL FRYFELLESL QYNLEERKRL QEFAVQALMN FEDK. It is sometimes possible for the material contained within the vial of "Cation channel sperm-associated protein 2 (Catsper2), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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