Rabbit F Polyclonal Antibody | anti-F antibody

F Antibody; FITC conjugated

Cat. Num. AAA7006358

• Reactivity: Human respiratory syncytial virus A
• Applications: ELISA
• Purity: >95%,Protein G purified
• Synonyms: F; Polyclonal Antibody; F Antibody; FITC conjugated; Fusion glycoprotein F0; Protein FCleaved into the following 4 chains:Fusion glycoprotein F2'1; anti-F antibody

• Host: Rabbit
• Reactivity: Human respiratory syncytial virus A
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >95%,Protein G purified
• Form/Format: Liquid
• Sequence Length: 574

• Applicable Applications for anti-F antibody: ELISA (EIA)
• Immunogen: Recombinant human respiratory syncytial virus A Fusion glycoprotein F0 protein
• Conjugation: FITC
• Storage Buffer: Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
• Preparation and Storage: Shipped at 4 degree C. Upon delivery, aliquot and store at -20 degree C or -80 degree C.

Related Product Information for anti-F antibody

During virus entry, induces fusion of viral and cellular membranes leading to delivery of the nucleocapsid into the cytoplasm. The fusogenic activity is inactive untill entry into host cell endosome, where a furin-like protease cleaves off a small peptide between F1 and F2 (PubMed:18216092). Interacts directly with heparan sulfate and may participates in virus attachment (PubMed:10864656). Furthermore, the F2 subunit was identifed as the major determinant of RSV host cell specificity (PubMed:11493675). Later in infection, proteins F expressed at the plasma membrane of infected cells can mediate fusion with adjacent cells to form syncytia, a cytopathic effect that could lead to tissue necrosis. The fusion protein is also able to trigger p53-dependent apoptosis (PubMed:12663767).

NCBI and Uniprot Product Information

• NCBI GI #: 138251
• UniProt Accession #: P03420; P88811
• Molecular Weight: 63,453 Da
• NCBI Official Full Name: Fusion glycoprotein F0
• UniProt Protein Name: Fusion glycoprotein F0
• Protein Family: Favin
• UniProt Gene Name: F
• UniProt Synonym Gene Names: Protein F
• UniProt Entry Name: FUS_HRSVA

Uniprot Description

During virus entry, induces fusion of viral and cellular membranes leading to delivery of the nucleocapsid into the cytoplasm. The fusogenic activity is inactive untill entry into host cell endosome, where a furin-like protease cleaves off a small peptide between F1 and F2 (PubMed:18216092). Interacts directly with heparan sulfate and may participates in virus attachment (PubMed:10864656). Furthermore, the F2 subunit was identifed as the major determinant of RSV host cell specificity (PubMed:11493675). Later in infection, proteins F expressed at the plasma membrane of infected cells can mediate fusion with adjacent cells to form syncytia, a cytopathic effect that could lead to tissue necrosis. The fusion protein is also able to trigger p53-dependent apoptosis (PubMed:12663767).