Rabbit anti-Human PPAP2B Polyclonal Antibody | anti-PPAP2B antibody

PPAP2B Antibody

Cat. Num. AAA7002383

• Gene Names: PLPP3; LPP3; VCIP; Dri42; PAP2B; PPAP2B
• Reactivity: Human
• Applications: ELISA, Western Blot, Immunohistochemistry, Immunofluorescence
• Purity: >95%,Protein G purified
• Synonyms: PPAP2B; Polyclonal Antibody; PPAP2B Antibody; Lipid phosphate phosphohydrolase 3; PAP2-beta; Phosphatidate phosphohydrolase type 2b; Phosphatidic acid phosphatase 2b; PAP-2b; PAP2b; Vascular endothelial growth factor and type I collagen-inducible protein; VCIP; LPP3; anti-PPAP2B antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >95%,Protein G purified
• Form/Format: Liquid
• Sequence Length: 311

• Applicable Applications for anti-PPAP2B antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
• Immunogen: Recombinant human Lipid phosphate phosphohydrolase 3 protein
• Conjugation: Non-conjugated
• Storage Buffer: Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
• Preparation and Storage: Shipped at 4 degree C. Upon delivery, aliquot and store at -20 degree C or -80 degree C.

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human lung cancer tissue using MBS7002383 at dilution of 1:100)

Immunofluorescence (IF)

(Immunofluorescent analysis of Hela cells using MBS7002383 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L))

Western Blot (WB)

(Western BlotPositive WB detected in:Mouse heart tissue,Mouse liver tissue,Mouse lung tissue,Mouse kidney tissue,Mouse brain tissueAll lanes: IL32 antibody at 3.4ug/mlSecondaryGoat polyclonal to rabbit IgG at 1/50000 dilutionPredicted band size: 27 kDaObserved band size: 27,30 kDa)

Related Product Information for anti-PPAP2B antibody

Catalyzes the conversion of phosphatidic acid (PA) to diacylglycerol (DG). In addition it hydrolyzes lysophosphatidic acid (LPA), ceramide-1-phosphate (C-1-P) and sphingosine-1-phosphate (S-1-P). The relative catalytic efficiency is LPA = PA > C-1-P > S-1-P. May be involved in cell adhesion and in cell-cell interactions.

NCBI and Uniprot Product Information

• NCBI GI #: 29171740
• NCBI GeneID: 8613
• NCBI Accession #: NP_003704.3
• NCBI GenBank Nucleotide #: NM_003713.4
• UniProt Accession #: O14495; Q5U0F7; Q96GW0; Q99782; B2R651; D3DQ52
• Molecular Weight: 35,116 Da
• NCBI Official Full Name: phospholipid phosphatase 3
• NCBI Official Synonym Full Names: phospholipid phosphatase 3
• NCBI Official Symbol: PLPP3
• NCBI Official Synonym Symbols: LPP3; VCIP; Dri42; PAP2B; PPAP2B
• NCBI Protein Information: phospholipid phosphatase 3
• UniProt Protein Name: Phospholipid phosphatase 3
• UniProt Gene Name: PLPP3
• UniProt Synonym Gene Names: PAP-2b; PAP2b; VCIP
• UniProt Entry Name: PLPP3_HUMAN

NCBI Description

The protein encoded by this gene is a member of the phosphatidic acid phosphatase (PAP) family. PAPs convert phosphatidic acid to diacylglycerol, and function in de novo synthesis of glycerolipids as well as in receptor-activated signal transduction mediated by phospholipase D. This protein is a membrane glycoprotein localized at the cell plasma membrane. It has been shown to actively hydrolyze extracellular lysophosphatidic acid and short-chain phosphatidic acid. The expression of this gene is found to be enhanced by epidermal growth factor in Hela cells. [provided by RefSeq, Mar 2010]

Uniprot Description

PPAP2B: Catalyzes the conversion of phosphatidic acid (PA) to diacylglycerol (DG). In addition it hydrolyzes lysophosphatidic acid (LPA), ceramide-1-phosphate (C-1-P) and sphingosine-1- phosphate (S-1-P). The relative catalytic efficiency is LPA = PA > C-1-P > S-1-P. May be involved in cell adhesion and in cell-cell interactions. Belongs to the PA-phosphatase related phosphoesterase family.

Protein type: Lipid Metabolism - sphingolipid; Phosphatase, lipid; Membrane protein, integral; Lipid Metabolism - glycerolipid; Membrane protein, multi-pass; EC 3.1.3.4; Lipid Metabolism - ether lipid; Motility/polarity/chemotaxis; Lipid Metabolism - glycerophospholipid

Chromosomal Location of Human Ortholog: 1p32.2

Cellular Component: adherens junction; endoplasmic reticulum membrane; Golgi apparatus; integral to plasma membrane; membrane; plasma membrane

Molecular Function: integrin binding; lipid phosphatase activity; phosphatidate phosphatase activity; phosphoprotein phosphatase activity; protein binding; sphingosine-1-phosphate phosphatase activity

Biological Process: Bergmann glial cell differentiation; blood vessel development; gastrulation with mouth forming second; germ cell migration; homotypic cell-cell adhesion; lipid metabolic process; negative regulation of protein amino acid phosphorylation; phospholipid dephosphorylation; phospholipid metabolic process; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of transcription factor activity; protein amino acid dephosphorylation; protein stabilization; regulation of Wnt receptor signaling pathway; sphingolipid biosynthetic process; sphingolipid metabolic process