Immunohistochemistry (IHC)
(Anti-PPAP2B antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 20 ug/ml.)
Rabbit anti-Human LPP3 / PPAP2B Polyclonal Antibody | anti-LPP3 antibody
Rabbit Polyclonal
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antib...
Immunohistochemistry (IHC)
(Anti-PPAP2B antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 20 ug/ml.)
Immunohistochemistry (IHC)
(Anti-PPAP2B antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 20 ug/ml.)
Western Blot (WB)
(Western blot of LPP3 antibody on bacterially expressed LPP3 protein when untreated (-) and treated with with 0.1 mM IPTG (iso propyl-beta-D- thiogalactopyranoside) (+) at a dilution of 10 ug/ml.)
Western Blot (WB)
(Western blot of LPP3 antibody on bacterially expressed LPP3 protein when untreated (-) and treated with with 0.1 mM IPTG (iso propyl-beta-D- thiogalactopyranoside) (+) at a dilution of 10 ug/ml.)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a member of the phosphatidic acid phosphatase (PAP) family. PAPs convert phosphatidic acid to diacylglycerol, and function in de novo synthesis of glycerolipids as well as in receptor-activated signal transduction mediated by phospholipase D. This protein is a membrane glycoprotein localized at the cell plasma membrane. It has been shown to actively hydrolyze extracellular lysophosphatidic acid and short-chain phosphatidic acid. The expression of this gene is found to be enhanced by epidermal growth factor in Hela cells. [provided by RefSeq, Mar 2010]
Uniprot Description
PPAP2B: Catalyzes the conversion of phosphatidic acid (PA) to diacylglycerol (DG). In addition it hydrolyzes lysophosphatidic acid (LPA), ceramide-1-phosphate (C-1-P) and sphingosine-1- phosphate (S-1-P). The relative catalytic efficiency is LPA = PA > C-1-P > S-1-P. May be involved in cell adhesion and in cell-cell interactions. Belongs to the PA-phosphatase related phosphoesterase family.
Protein type: Membrane protein, integral; Lipid Metabolism - glycerolipid; Lipid Metabolism - ether lipid; Lipid Metabolism - sphingolipid; Lipid Metabolism - glycerophospholipid; Membrane protein, multi-pass; Motility/polarity/chemotaxis; EC 3.1.3.4; Phosphatase, lipid
Chromosomal Location of Human Ortholog: 1p32.2
Cellular Component: Golgi apparatus; adherens junction; membrane; plasma membrane; integral to membrane
Molecular Function: integrin binding; protein binding; phosphatidate phosphatase activity; lipid phosphatase activity; phosphoprotein phosphatase activity; sphingosine-1-phosphate phosphatase activity
Biological Process: blood vessel development; sphingolipid metabolic process; sphingolipid biosynthetic process; protein stabilization; regulation of Wnt receptor signaling pathway; gastrulation with mouth forming second; Bergmann glial cell differentiation; positive regulation of peptidyl-tyrosine phosphorylation; dephosphorylation; negative regulation of protein amino acid phosphorylation; phospholipid metabolic process; germ cell migration; homotypic cell-cell adhesion; positive regulation of transcription factor activity; lipid metabolic process
Research Articles on LPP3
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Product Notes
The LPP3 ppap2b (Catalog #AAA240291) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Rabbit Polyclonal reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's LPP3 / PPAP2B can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC - Paraffin), Western Blot (WB). IHC-P (20 ug/ml), WB Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antib.. Researchers should empirically determine the suitability of the LPP3 ppap2b for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "LPP3 / PPAP2B, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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