Oncostatin M Active Protein | OSM active protein

Human Oncostatin M (209 a.a.)

Cat. Num. AAA695797

• Reactivity: Species Reactivity: Human
• Purity: Above 98% as determined by SDS-PAGE Analysis.
• Synonyms: Oncostatin M; Human Oncostatin M (209 a.a.); Recombinant Human Oncostatin-M (209 a.a.); OSM active protein

• Host: E Coli
• Reactivity: Species Reactivity: Human
• Purity/Purification: Above 98% as determined by SDS-PAGE Analysis.
• Sequence: AAIGSCSKE YRVLLGQLQ KQTDLMQDT SRLLDPYIR IQGLDVPKL REHCRERPG AFPSEETLR GLGRRGFLQ TLNATLGCV LHRLADLEQ RLPKAQDLE RSGLNIEDL EKLQMARPN ILGLRNNIY CMAQLLDNS DTAEPTKAG RGASQPPTP TPASDAFQR KLEGCRFLH GYHRFMHSV GRVFSKWGE SPNRSRRHS PHQALRKGV RR

• Biological Activity: The ED50as determined by the dose-dependent stimulation of the proliferation of human TF-1 cells is <= 2.0 ng/ml, corresponding to a specific activity of >= 5 x 105 units/mg.
• Cell Type: Monocytes and Macrophages, T Cells, Dendritic Cells
• Preparation and Storage: At -20 degree C

Testing Data

Related Product Information for OSM active protein

Oncostatin M (OSM) is a growth and differentiation factor that participates in the regulation of neurogenesis, osteogenesis and hematopoiesis. Produced by activate T cells, monocytes and Kaposi's sarcoma cells, OSH can exert both stimulatory and inhibitory effects on cell proliferation. It stimulates the proliferation of fibroblasts, smooth muscle cells and Kaposi's sarcoma cells, but, inhibits the growth of some normal and tumor cell lines. It also promotes cytokine release (e.g. IL-6, GM-CSF and G-CSF) from endothelial cells, and enhances the expression of low-density lipoprotein receptor in hepatoma cells. OSM share several structural and functional characteristics with LIF, IL-6, and CNTF. Human OSM is active on murine cells. The human OSM gene encodes for a 252 amino acid polypeptide, containing 25 amino acid signal sequence for secretion and a 227 precursor protein. Proteolytic processing of this precursor removes an 18 amino acid C-terminal peptide and generates the mature OSM form. Recombinant human Oncostatin M is a 23.6 kDa protein, containing 209 amino acid residues.

Product Categories/Family for OSM active protein

Innate Immunity; Stem Cell Research; Immunology; Angiogenesis; Bone Biology; Inflammation

NCBI and Uniprot Product Information

• NCBI GI #: 129168
• NCBI GeneID: 5008
• UniProt Accession #: P13725; Q6FHP8; Q9UCP6
• Molecular Weight: 28,484 Da
• NCBI Official Full Name: Oncostatin-M
• NCBI Official Synonym Full Names: oncostatin M
• NCBI Official Symbol: OSM
• NCBI Protein Information: oncostatin-M
• UniProt Protein Name: Oncostatin-M
• Protein Family: Oncostatin
• UniProt Gene Name: OSM
• UniProt Synonym Gene Names: OSM
• UniProt Entry Name: ONCM_HUMAN

NCBI Description

Oncostatin M is a member of a cytokine family that includes leukemia-inhibitory factor, granulocyte colony-stimulating factor, and interleukin 6. This gene encodes a growth regulator which inhibits the proliferation of a number of tumor cell lines. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. [provided by RefSeq, Jul 2008]

Uniprot Description

OSM: Growth regulator. Inhibits the proliferation of a number of tumor cell lines. Stimulates proliferation of AIDS-KS cells. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. Uses both type I OSM receptor (heterodimers composed of LIPR and IL6ST) and type II OSM receptor (heterodimers composed of OSMR and IL6ST). Involved in the maturation of fetal hepatocytes, thereby promoting liver development and regeneration. Belongs to the LIF/OSM family.

Protein type: Secreted, signal peptide; Secreted; Cytokine

Chromosomal Location of Human Ortholog: 22q12.2

Cellular Component: extracellular space

Molecular Function: growth factor activity; oncostatin-M receptor binding; cytokine activity

Biological Process: negative regulation of hormone secretion; multicellular organismal development; tyrosine phosphorylation of Stat3 protein; tyrosine phosphorylation of Stat5 protein; positive regulation of peptidyl-serine phosphorylation; peripheral nervous system development; negative regulation of cell proliferation; cell proliferation; positive regulation of peptidyl-tyrosine phosphorylation; behavioral response to pain; positive regulation of MAPKKK cascade; response to heat; positive regulation of acute inflammatory response; positive regulation of cell division; regulation of growth; negative regulation of meiosis; positive regulation of cell proliferation; tyrosine phosphorylation of Stat1 protein; immune response; positive regulation of transcription from RNA polymerase II promoter