Testing Data
Oncostatin M Active Protein | Osm active protein
Rat Oncostatin M
Reactivity
Species Reactivity: Rat
Purity
Above 98% as determined by SDS-PAGE Analysis.
Synonyms
Oncostatin M; Rat Oncostatin M; Recombinant Rat Oncostatin M; Osm active protein
Host
E Coli
Reactivity
Species Reactivity: Rat
Purity/Purification
Above 98% as determined by SDS-PAGE Analysis.
Sequence
MKRGCSSSS PKLLSQLKS QANITGNTA SLLEPYILH QNLNTLTLR AACTEHPVA FPSEDMLRQ LSKPDFLST VHATLGRVW HQLGAFRQQ FPKIQDFPE LERARQNIQ GIRNNVYCM ARLLHPPLE IPEPTQADS GTSRPTTTA PGIFQIKID SCRFLWGYH RFMGSVGRV FEEWGDGSR RSRRHSPLW AWLKGDHRI RPSRSSQSA MLRSLVPR
Biological Activity
Assay #1:Determined by its ability to stimulate the proliferation of rat C6 cells. The expected ED50 is 3.0-5.0 mug/ml. Assay #2: Determined by its ability to inhibit Alkaline phosphata
Cell Type
Monocytes and Macrophages, T Cells, Dendritic Cells
Preparation and Storage
At -20 degree C
Testing Data
Testing Data
Related Product Information for Osm active protein
Oncostatin M (OSM) is a growth and differentiation factor that participates in the regulation of neurogenesis, osteogenesis and hematopoiesis. Produced by activated T cells, monocytes and Kaposi's sarcoma cells, OSM can exert both stimulatory and inhibitory effects on cell proliferation. It stimulates the proliferation of fibroblasts, smooth muscle cells and Kaposi's sarcoma cells, but, inhibits the growth of some normal and tumor cell lines. It also promotes cytokine release (e.g. IL-6, GM-CSF and G-CSF) from endothelial cells, and enhances the expression of low-density lipoprotein receptor in hepatoma cells. OSM share several structural and functional characteristics with LIF, IL-6, and CNTF. Human OSM is active on murine cells. Recombinant rat Oncostatin M is a 24.4 kDa protein, containing 215 amino acid residues.
Product Categories/Family for Osm active protein
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
UniProt Accession #
Molecular Weight
27,106 Da
NCBI Official Full Name
Oncostatin-M
NCBI Official Synonym Full Names
oncostatin M
NCBI Official Symbol
Osm
NCBI Protein Information
oncostatin-M
UniProt Protein Name
Oncostatin-M
Protein Family
UniProt Gene Name
Osm
UniProt Synonym Gene Names
OSM
UniProt Entry Name
ONCM_RAT
NCBI Description
mouse homolog is a cytokine and an immediate early gene [RGD, Feb 2006]
Uniprot Description
Growth regulator. Inhibits the proliferation of a number of tumor cell lines. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells (). Uses only type II OSM receptor (heterodimers composed of OSMR and IL6ST). Involved in the maturation of fetal hepatocytes, thereby promoting liver development and regeneration.
Research Articles on Osm
Similar Products
Product Notes
The Osm osm (Catalog #AAA695929) is an Active Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The Rat Oncostatin M reacts with Species Reactivity: Rat and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: MKRGCSSSS PKLLSQLKS QANITGNTA SLLEPYILH QNLNTLTLR AACTEHPVA FPSEDMLRQ LSKPDFLST VHATLGRVW HQLGAFRQQ FPKIQDFPE LERARQNIQ GIRNNVYCM ARLLHPPLE IPEPTQADS GTSRPTTTA PGIFQIKID SCRFLWGYH RFMGSVGRV FEEWGDGSR RSRRHSPLW AWLKGDHRI RPSRSSQSA MLRSLVPR. It is sometimes possible for the material contained within the vial of "Oncostatin M, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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