GASP-1 active protein

Human GASP-1

Cat. Num. AAA691886

• Gene Names: GPRASP1; GASP; GASP1; GASP-1
• Reactivity: Human
• Purity: 97 % (SDS-PAGE, HPLC)
• Synonyms: GASP-1; Human GASP-1; Recombinant Human PDGF-AA; GASP-1 active protein

• Host: CHO Cells
• Reactivity: Human
• Purity/Purification: 97 % (SDS-PAGE, HPLC)
• Form/Format: Lyophilized
• Sequence: LPPIRYSHAG ICPNDMNPNL WVDAQSTCRR ECETDQECET YEKCCP NVCG TKSCVAARYM DVKGKKGPVG MPKEATCDHF MCLQQGSECD I WDGQPVCKC KDRCEKEPSF TCASDGLTYY NRCYMDAEAC SKGITLA VVT CRYHFTWPNT SPPPPETTMH PTTASPETPE LDMAAPALLN NP VHQSVTMG ETVSFLCDVV GRPRPEITWE KQLEDRENVV MRPNHVRG NV VVTNIAQLVI YNAQLQDAGI YTCTARNVAG VLRADFPLSV VRG HQAAATS ESSPNGTAFP AAECLKPPDS EDCGEEQTRW HFDAQANNC L TFTFGHCHRN LNHFETYEAC MLACMSGPLA ACSLPALQGP CKAY APRWAY NSQTGQCQSF VYGGCEGNGN NFESREACEE SCPFPRGNQR CRACKPRQKL VTSFCRSDFV ILGRVSELTE EPDSGRALVT VDEVL KDEKM GLKFLGQEPL EVTLLHVDWA CPCPNVTVSE MPLIIMGEVD GGMAMLRPDS FVGASSARRV RKLREVMHKK TCDVLKEFLG LH
• Sequence Length: 1395

• Endotoxin Level: < 0.1 ng per ug of PDGF-AA
• Buffer: none

Related Product Information for GASP-1 active protein

Growth and differentiation factor-associated serum protein-1 (GASP-1) is a secreted inhibitory TGF-beta binding protein that contains multiple protease inhibitor structural domains. It is expressed primarily in the ovary, testis, and brain, and can act as a potent soluble inhibitor of myostatin and GDF-11, but not Activin-A. The GASP-1 gene encodes a 571 amino acid protein that contains a 29 amino acid secretion signal sequence, and multiple identifiable structural features, including a WAP domain, a follistatin/Kazal domain, an immunoglobulin domain, two tandem Kunitz domains, and a netrin domain. Recombinant human GASP-1 is a 542 amino acid protein that migrates at an apparent molecular weight of approximately 55-66 kDa by SDS-PAGE analysis under non-reducing conditions.

Product Categories/Family for GASP-1 active protein

Cytokines & Growth Factors

NCBI and Uniprot Product Information

• NCBI GI #: 150378489
• NCBI GeneID: 9737
• NCBI Accession #: NP_001092880.1
• NCBI GenBank Nucleotide #: NM_001099410.1
• UniProt Accession #: Q5JY77; O43168; Q96LA1
• Molecular Weight: 28.5 kDa
• NCBI Official Full Name: G-protein coupled receptor-associated sorting protein 1
• NCBI Official Synonym Full Names: G protein-coupled receptor associated sorting protein 1
• NCBI Official Symbol: GPRASP1
• NCBI Official Synonym Symbols: GASP; GASP1; GASP-1
• NCBI Protein Information: G-protein coupled receptor-associated sorting protein 1
• UniProt Protein Name: G-protein coupled receptor-associated sorting protein 1
• UniProt Gene Name: GPRASP1
• UniProt Synonym Gene Names: GASP; KIAA0443; GASP-1
• UniProt Entry Name: GASP1_HUMAN

NCBI Description

This gene encodes a member of the GPRASP (G protein-coupled receptor associated sorting protein) family. The protein may modulate lysosomal sorting and functional down-regulation of a variety of G-protein coupled receptors. It targets receptors for degradation in lysosomes. The receptors interacting with this sorting protein include D2 dopamine receptor (DRD2), delta opioid receptor (OPRD1), beta-2 adrenergic receptor (ADRB2), D4 dopamine receptor (DRD4) and cannabinoid 1 receptor (CB1R). Multiple alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, May 2010]

Uniprot Description

Function: Modulates lysosomal sorting and functional down-regulation of a variety of G-protein coupled receptors. Targets receptors for degradation in lysosomes via its interaction with BECN1P1/BECN2. Ref.5 Ref.6 Ref.8

Subunit structure: Interacts with cytoplasmic tails of a variety of G-protein coupled receptors such as D2 dopamine receptor/DRD2

By similarity, delta opioid receptor/OPRD1, beta-2 adrenergic receptor/ADRB2 and D4 dopamine receptor/DRD4. Interacts with PER1. Interacts with BECN1P1/BECN2; the interaction is direct. Ref.5 Ref.6 Ref.7 Ref.8

Subcellular location: Cytoplasm Ref.6.

Tissue specificity: Expressed in the brain, with lower expression in medulla, spinal cord and substantia nigra. Ref.5 Ref.7

Sequence similarities: Belongs to the GPRASP family.

Sequence caution: The sequence BAA23715.3 differs from that shown. Reason: Erroneous initiation.