BMP-13 (GDF6) active protein
Human BMP-13 (GDF6)
NCBI and Uniprot Product Information
Uniprot Description
Function: Growth factor that controls proliferation and cellular differentiation in the retina and bone formation. Plays a key role in regulating apoptosis during retinal development. Establishes dorsal-ventral positional information in the retina and controls the formation of the retinotectal map. Required for normal formation of bones and joints in the limbs, skull, and axial skeleton. Plays a key role in establishing boundaries between skeletal elements during development. May signal through the growth factor receptors subunits BMPR1A, BMPR1B, BMPR2 and ACVR2A. Ref.3 Ref.4 Ref.5
Subunit structure: Homodimer; disulfide-linked
By similarity.
Subcellular location: Secreted
By similarity.
Tissue specificity: Expressed in different subsets of developing joints. Ref.3
Disruption phenotype: Mice lacking Gdf6 display photoreceptor degeneration. Animals exhibit abnormal electroretinograms with up to 66% decreases in the bipolar cell-driven b-wave and 54% decreases in the photoreceptor-mediated a-wave amplitudes, as well as 3 to 27% reduced photopic flicker fusion. Ref.5
Sequence similarities: Belongs to the TGF-beta family.
Research Articles on BMP-13 (GDF6)
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Product Notes
The BMP-13 (GDF6) gdf6 (Catalog #AAA691856) is an Active Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The Human BMP-13 (GDF6) reacts with Human and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: TAFASRHGKR HGKKSRLRCS KKPLHVNFKE LGWDDWIIAP LEYEAY HCEG VCDFPLRSHL EPTNHAIIQT LMNSMDPGST PPSCCVPTKL T PISILYIDA GNNVVYKQYE DMVVESCGCR. It is sometimes possible for the material contained within the vial of "BMP-13 (GDF6), Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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