Follistatin Active Protein | FST active protein
Human Follistatin
NCBI and Uniprot Product Information
NCBI Description
Follistatin is a single-chain gonadal protein that specifically inhibits follicle-stimulating hormone release. The single FST gene encodes two isoforms, FST317 and FST344 containing 317 and 344 amino acids respectively, resulting from alternative splicing of the precursor mRNA. In a study in which 37 candidate genes were tested for linkage and association with polycystic ovary syndrome (PCOS) or hyperandrogenemia in 150 families, evidence was found for linkage between PCOS and follistatin. [provided by RefSeq, Jul 2008]
Uniprot Description
Function: Binds directly to activin and functions as an activin antagonist. Specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (FSH).
Subunit structure: Monomer
Potential.
Subcellular location: Secreted.
Tissue specificity: Isoform 1 is the predominant isoform inserum but is undetectable in follicular fluid. Ref.6
Sequence similarities: Contains 3 follistatin-like domains.Contains 3 Kazal-like domains.Contains 1 TB (TGF-beta binding) domain.
Research Articles on FST
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Product Notes
The FST fst (Catalog #AAA691793) is an Active Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The Human Follistatin reacts with Human and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: GNCWLRQAKN GRCQVLYKTE LSKEECCSTG RLSTSWTEED VNDNTL FKWM IFNGGAPNCI PCKETCENVD CGPGKKCRMN KKNKPRCVCA P DCSNITWKG PVCGLDGKTY RNECALLKAR CKEQPELEVQ YQGRCKK TCR DVFCPGSSTC VVDQTNNAYC VTCNRICPEP ASSEQYLCGN DG VTYSSACH LRKATCLLGR SIGLAYEGKC IKAKSCEDIQ CTGGKKCL WD FKVGRGRCSL CDELCPDSKS DEPVCASDNA TYASECAMKE AAC SSGVLLE VKHSGSCN. It is sometimes possible for the material contained within the vial of "Follistatin, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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