Western Blot (WB)
(Western Blot detection against Immunogen (36.74kD).)
Mouse anti-Human CSE1L Monoclonal Antibody | anti-CSE1L antibody
CSE1L (Chromosome Segregation 1-like Protein, Cellular Apoptosis Susceptibility Protein, CAS, CSE1, Exportin-2, Exp2, Importin-alpha Re-exporter, XPO2) (AP)
Western Blot (WB)
(Western Blot detection against Immunogen (36.74kD).)
Western Blot (WB)
(Western Blot detection against Immunogen (36.74kD).)
Western Blot (WB)
(CSE1L monoclonal antibody. Western Blot analysis of CSE1L expression in MCF-7.)
Western Blot (WB)
(CSE1L monoclonal antibody. Western Blot analysis of CSE1L expression in MCF-7.)
Immunohistochemistry (IHC)
(Immunoperoxidase of monoclonal antibody to CSE1L on formalin-fixed paraffin-embedded human colon. [antibody concentration 3ug/ml].)
Immunohistochemistry (IHC)
(Immunoperoxidase of monoclonal antibody to CSE1L on formalin-fixed paraffin-embedded human colon. [antibody concentration 3ug/ml].)
Immunofluorescence (IF)
(Immunofluorescence of monoclonal antibody to CSE1L on HeLa cell. [antibody concentration 10ug/ml].)
Immunofluorescence (IF)
(Immunofluorescence of monoclonal antibody to CSE1L on HeLa cell. [antibody concentration 10ug/ml].)
Testing Data
(Detection limit for recombinant GST tagged CSE1L is ~0.3ng/ml as a capture antibody)
Testing Data
(Detection limit for recombinant GST tagged CSE1L is ~0.3ng/ml as a capture antibody)
NCBI and Uniprot Product Information
Uniprot Description
Exportin-2: Export receptor for importin-alpha. Mediates importin- alpha re-export from the nucleus to the cytoplasm after import substrates (cargos) have been released into the nucleoplasm. In the nucleus binds cooperatively to importin-alpha and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the importin-alpha from the export receptor. CSE1L/XPO2 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Belongs to the XPO2/CSE1 family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Nuclear import; Karyopherin; Nuclear export
Chromosomal Location of Human Ortholog: 20q13
Cellular Component: nucleoplasm; membrane; cytoplasm; nucleus
Molecular Function: protein binding; importin-alpha export receptor activity; Ran GTPase binding
Biological Process: cell proliferation; apoptosis; protein export from nucleus
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Product Notes
The CSE1L cse1l (Catalog #AAA6130770) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The CSE1L (Chromosome Segregation 1-like Protein, Cellular Apoptosis Susceptibility Protein, CAS, CSE1, Exportin-2, Exp2, Importin-alpha Re-exporter, XPO2) (AP) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's CSE1L can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Immunohistochemistry (IHC), Western Blot (WB). Applications are based on unconjugated antibody. Researchers should empirically determine the suitability of the CSE1L cse1l for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CSE1L, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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