EG-VEGF active protein
Mouse EG-VEGF
NCBI and Uniprot Product Information
Uniprot Description
Function: Potently contracts gastrointestinal (GI) smooth muscle. Induces proliferation, migration and fenestration (the formation of membrane discontinuities) in capillary endothelial cells. Induces proliferation and differentiation, but not migration, of enteric neural crest cells. Directly influences neuroblastoma progression by promoting the proliferation and migration of neuroblastoma cells. Positively regulates PTGS2 expression and prostaglandin synthesis. May play a role in placentation. May play a role in normal and pathological testis angiogenesis. Ref.1 Ref.5 Ref.6 UniProtKB P58294
Subcellular location: Secreted
By similarity UniProtKB P58294.
Tissue specificity: Highly expressed in liver and ovary and weakly expressed in testis and placenta. Expressed in mucosa and mesenchyme of embryonic gut during enteric nervous system development (at protein level). Predominantly expressed in kidney and liver. Also expressed in lung, ovary, placenta and testis. In fetal liver, is restricted to and highly expressed in hepatocytes. In adult kidney, expression is restricted to the endothelial tubule cells. In placenta, expressed throughout gestation. Ref.1 Ref.5 Ref.6
Developmental stage: In placenta, at 7.5 dpc highly expressed in ectoplacental cone, endoderm and in giant cells, and at 9.5 dpc restricted mainly to the labyrinth layer (at protein level). In placenta, most highly expressed during early gestation (between 9.5 and 10.5 dpc). Ref.6
Sequence similarities: Belongs to the AVIT (prokineticin) family.
Research Articles on EG-VEGF
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Product Notes
The EG-VEGF prok1 (Catalog #AAA691769) is an Active Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The Mouse EG-VEGF reacts with Mouse and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: AVITGACERD IQCGAGTCCA ISLWLRGLRL CTPLGREGEE CHPGSH KIPF LRKRQHHTCP CSPSLLCSRF PDGRYRCFRD LKNANF. It is sometimes possible for the material contained within the vial of "EG-VEGF, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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