IL-3 active protein

Human IL-3

Cat. Num. AAA691744

• Gene Names: IL3; IL-3; MCGF; MULTI-CSF
• Reactivity: Human
• Purity: > 98% by SDS-PAGE & silver stain
• Synonyms: IL-3; Human IL-3; Recombinant Human Interleukin-3; Hemapoietic growth factor; Mast cell growth factor; P-cell-stimulating factor; IL-3 active protein

• Host: E Coli
• Reactivity: Human
• Purity/Purification: > 98% by SDS-PAGE & silver stain
• Form/Format: Lyophilized
• Sequence: N-Terminal Sequence: MAPMTQT
• Sequence Length: 134

• Endotoxin Level: < 0.1ng per ug (IEU/ug) of rh IL-3
• Buffer: PBS
• Preparation and Storage: The lyophilized IL-3, though stable at room temperature, is best stored desiccated below 0 degree C. Reconstituted IL-3 should be stored in working aliquots at -20 degree C.

Testing Data

Testing Data #2

Related Product Information for IL-3 active protein

IL-3 is a hematopoietic growth factor that promotes the survival, differentiation and proliferation of committed progenitor cells of the megakaryocyte, granulocyte-macrophage, erythroid, eosinophil, basophil and mast cell lineages. Produced by T cells, mast cells and eosinophils, IL-3 enhances thrombopoieses, phagocytosis, and antibody-mediated cellular cytotoxicity. Its ability to activate monocytes suggests that IL-3 may have additional immunoregulatory roles. Many of the IL-3 activities depend upon co-stimulation with other cytokines. IL-3 is species-specific, variably glycosylated cytokine. Recombinant human IL-3 is a 15.0 kDa globular protein containing 133 amino acid residues.

Product Categories/Family for IL-3 active protein

Cytokines & Growth Factors

References

1. Ma, A. et al. (2006) Annu. Rev. Immunol. 24:657. 2. Gaffen, S.L. and K.D. Liu (2004) Cytokine 28:109. 3. Taniguchi, T. et al. (1983) Nature 302:305. 4. Mosmann, T.R. et al. (1987) J. Immunol. 138:1813. 5. Liparoto, S.F. et al. (2002) Biochemistry 41:2543. 6. Wang, X. et al. (2005) Science 310:1159. 7. Bodnar, A. et al. (2008) Immunol. Lett. 116:117. 8. Jaleco, S. et al. (2003) J. Immunol. 171:61. 9. Malek, T.R. (2003) J. Leukoc. Biol. 74:961.

NCBI and Uniprot Product Information

• NCBI GI #: 28416915
• NCBI GeneID: 3562
• NCBI Accession #: NP_000579
• NCBI GenBank Nucleotide #: NM_000588
• UniProt Accession #: P08700; Q6GS87
• Molecular Weight: 15.0 kDa
• NCBI Official Full Name: interleukin-3
• NCBI Official Synonym Full Names: interleukin 3 (colony-stimulating factor, multiple)
• NCBI Official Symbol: IL3
• NCBI Official Synonym Symbols: IL-3; MCGF; MULTI-CSF
• NCBI Protein Information: interleukin-3; mast cell growth factor; mast-cell growth factor; P-cell stimulating factor; P-cell-stimulating factor; hematopoietic growth factor; multilineage-colony-stimulating factor; multipotential colony-stimulating factor
• UniProt Protein Name: Interleukin-3
• UniProt Gene Name: IL3
• UniProt Synonym Gene Names: IL-3; MCGF
• UniProt Entry Name: IL3_HUMAN

NCBI Description

The protein encoded by this gene is a potent growth promoting cytokine. This cytokine is capable of supporting the proliferation of a broad range of hematopoietic cell types. It is involved in a variety of cell activities such as cell growth, differentiation and apoptosis. This cytokine has been shown to also possess neurotrophic activity, and it may be associated with neurologic disorders. [provided by RefSeq, Jul 2008]

Uniprot Description

Function: Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages.This CSF induces granulocytes, macrophages, mast cells, stem cells, erythroid cells, eosinophils and megakaryocytes.

Subunit structure: Monomer.

Subcellular location: Secreted.

Tissue specificity: Activated T-cells, mast cells, natural killer cells.

Sequence similarities: Belongs to the IL-3 family.