IL-3 active protein

Human IL-3

Cat. Num. AAA695716

• Gene Names: IL3; IL-3; MCGF; MULTI-CSF
• Reactivity: Species Reactivity: Human; Cross Reactivity: Monkey, Human, Mouse
• Purity: Above 98% as determined by SDS-PAGE Analysis.
• Synonyms: IL-3; Human IL-3; Recombinant Human IL-3; IL-3 active protein

• Host: E Coli
• Reactivity: Species Reactivity: Human; Cross Reactivity: Monkey, Human, Mouse
• Purity/Purification: Above 98% as determined by SDS-PAGE Analysis.
• Sequence: APMTQTTSL KTSWVNCSN MIDEIITHL KQPPLPLLD FNNLNGEDQ DILMENNLR RPNLEAFNR AVKSLQNAS AIESILKNL LPCLPLATA APTRHPIHI KDGDWNEFR RKLTFYLKT LENAQAQQT TLSLAIF

• Biological Activity: The ED50 as determined by the dose-dependent stimulation of the proliferation of human TF-1 cells is <= 0.1 ng/ml, corresponding to a specific activity of >= 1 x 107 units/mg.
• Cell Type: Monocytes and Macrophages, T Cells, Stem Cells
• Preparation and Storage: At -20 degree C

Testing Data

Related Product Information for IL-3 active protein

IL-3 is a hematopoietic growth factor that promotes the survival, differentiation and proliferation of committed progenitor cells of the megakaryocyte, granulocyte-macrophage, erythroid, eosinophil, basophil and mast cell lineages. Produced by T cells, mast cells and eosinophils, IL-3 enhances thrombopoieses, phagocytosis, and antibody-mediated cellular cytotoxicity. Its ability to activate monocytes suggests that IL-3 may have additional immunoregulatory roles. Many of the IL-3 activities depend upon co-stimulation with other cytokines. IL-3 is species-specific, variably glycosylated cytokine. Recombinant human IL-3 is a 15.0 kDa globular protein containing 133 amino acid residues.

Product Categories/Family for IL-3 active protein

Innate Immunity; Adaptive Immunity; Stem Cell Research; Cancer; Proliferation and Cell Cycle

NCBI and Uniprot Product Information

• NCBI GI #: 124330
• NCBI GeneID: 3562
• UniProt Accession #: P08700; Q6GS87
• Molecular Weight: 17,233 Da
• NCBI Official Full Name: Interleukin-3
• NCBI Official Synonym Full Names: interleukin 3
• NCBI Official Symbol: IL3
• NCBI Official Synonym Symbols: IL-3; MCGF; MULTI-CSF
• NCBI Protein Information: interleukin-3; mast cell growth factor; mast-cell growth factor; P-cell stimulating factor; P-cell-stimulating factor; hematopoietic growth factor; colony-stimulating factor, multiple; multilineage-colony-stimulating factor; multipotential colony-stimulating factor
• UniProt Protein Name: Interleukin-3
• UniProt Gene Name: IL3
• UniProt Synonym Gene Names: IL-3; MCGF
• UniProt Entry Name: IL3_HUMAN

NCBI Description

The protein encoded by this gene is a potent growth promoting cytokine. This cytokine is capable of supporting the proliferation of a broad range of hematopoietic cell types. It is involved in a variety of cell activities such as cell growth, differentiation and apoptosis. This cytokine has been shown to also possess neurotrophic activity, and it may be associated with neurologic disorders. [provided by RefSeq, Jul 2008]

Uniprot Description

IL3: Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. Belongs to the IL-3 family.

Protein type: Cell cycle regulation; Secreted; Cytokine; Oncoprotein; Apoptosis; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 5q31.1

Cellular Component: extracellular space; extracellular region

Molecular Function: interleukin-3 receptor binding; growth factor activity; cytokine activity

Biological Process: nervous system development; positive regulation of peptidyl-tyrosine phosphorylation; cell-cell signaling; positive regulation of tyrosine phosphorylation of Stat5 protein; embryonic hemopoiesis; cytokine and chemokine mediated signaling pathway; positive regulation of cell proliferation; immune response; positive regulation of myeloid leukocyte differentiation; positive regulation of DNA replication