Angiopoietin-like protein 3 Active Protein | ANGPTL3 active protein
Human Angiopoietin-like protein 3
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of a family of secreted proteins that function in angiogenesis. The encoded protein, which is expressed predominantly in the liver, is further processed into an N-terminal coiled-coil domain-containing chain and a C-terminal fibrinogen chain. The N-terminal chain is important for lipid metablism, while the C-terminal chain may be involved in angiogenesis. Mutations in this gene cause familial hypobetalipoproteinemia type 2. [provided by RefSeq, Feb 2013]
Uniprot Description
Subunit structure: Interacts with C19orf80/ANGPTL8. Ref.9
Subcellular location: Secreted
By similarity.
Tissue specificity: Expressed principally in liver. Weakly expressed in kidney. Ref.1
Involvement in disease: Hypobetalipoproteinemia, familial, 2 (FHBL2) [MIM:605019]: A disorder of lipid metabolism characterized by less than 5th percentile age- and sex-specific levels of low density lipoproteins, and dietary fat malabsorption. Affected individuals present with combined hypolipidemia, consisting of extremely low plasma levels of LDL cholesterol, HDL cholesterol, and triglycerides.Note: The disease is caused by mutations affecting the gene represented in this entry.
Sequence similarities: Contains 1 fibrinogen C-terminal domain.
Research Articles on ANGPTL3
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Product Notes
The ANGPTL3 angptl3 (Catalog #AAA691488) is an Active Protein produced from CHO Cells and is intended for research purposes only. The product is available for immediate purchase. The Human Angiopoietin-like protein 3 reacts with Human and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: SRIDQDNSSF DSLSPEPKSR FAMLDDVKIL ANGLLQLGHG LKDFVH KTKG QINDIFQKLN IFDQSFYDLS LQTSEIKEEE KELRRTTYKL Q VKNEEVKNM SLELNSKLES LLEEKILLQQ KVKYLEEQLT NLIQNQP ETP EHPEVTSLKT FVEKQDNSIK DLLQTVEDQY KQLNQQHSQI KE IENQLRRT SIQEPTEISL SSKPRAPRTT PFLQLNEIRN VKHDGIPA EC TTIYNRGEHT SGMYAIRPSN SQVFHVYCDV ISGSPWTLIQ HRI DGSQNFN ETWENYKYGF GRLDGEFWLG LEKIYSIVKQ SNYVLRIEL E DWKDNKHYIE YSFYLGNHET NYTLHLVAIT GNVPNAIPEN KDLV FSTWDH KAKGHFNCPE GYSGGWWWHD ECGENNLNGK YNKPRAKSKP ERRRGLSWKS QNGRLYSIKS TKMLIHPTDS ESFEHHHHHH HH. It is sometimes possible for the material contained within the vial of "Angiopoietin-like protein 3, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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